ArticleScience advances2025
Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling.
Abstract read
In one paragraph
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- Adolescent and adult stress alter excitatory-inhibitory network dynamics in the medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Inferring intrinsic neural timescales using optimal control theory.Nature communications · 2025Article
- The effective connectome over a century of human life.Communications biology · 2025Article
- cuBNM: GPU-Accelerated Brain Network Modeling.bioRxiv : the preprint server for biology · 2025Article
- Disentangling metabolic and neurovascular timescales supporting cognitive processes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Excitation/inhibition imbalance and conversion to psychosis in the clinical high risk syndrome: Biophysical modeling finds reduced pyramidal cell excitability across EEG paradigms.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
- Update of
Authors and funding
37 authors.
Amin SaberiInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0002-7043-0722
Kevin J WischnewskiInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0003-3294-5706
Kyesam JungInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0003-3334-5462
Leon D LotterInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0002-2337-6073
H Lina SchaareInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0003-4259-0793
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.ORCID 0000-0003-4595-1144
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-5214-7421
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0003-0114-4914
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-9120-7060
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.ORCID 0000-0003-4809-5398
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0002-8939-1014
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.ORCID 0000-0002-4900-4817
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0001-5405-9065
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.ORCID 0000-0003-0111-5996
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U1299 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.ORCID 0000-0002-0136-0388
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U1299 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.ORCID 0000-0002-0452-2450
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM U1299 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.ORCID 0000-0003-4461-7646
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.ORCID 0000-0002-7796-8234
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.ORCID 0000-0002-1242-8990
Herve LemaitreNeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.ORCID 0000-0002-5952-076X
Luise PoustkaDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-7738-4394
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.ORCID 0000-0002-6225-9267
Christian BaeuchlDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0001-5615-3645
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0001-5398-5569
Nilakshi VaidyaCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0002-2790-7281
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-7740-6469
IMAGEN Consortium
Tomáš PausDepartments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Juergen DukartInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0003-0492-5644
Boris C BernhardtMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.
Oleksandr V PopovychInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0001-9994-1764
Simon B EickhoffInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
Sofie L ValkInstitute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0003-2998-6849
Funding
Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M2/2 Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089924 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2009 to 2011
$10.7MMeta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MA decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9MENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kNIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238NIMH NIH HHS R01 MH074457NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2 MH089983
Abstract
The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual's lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (
Indexed as
Cerebral CortexModels, NeurologicalNerve NetAdolescentFemaleHumansMagnetic Resonance ImagingMale
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.