Evidence map›Paper›PMID 40465625›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Macropinosomes are a site of HIV-1 entry into primary CD4

Tomoyuki Murakami, Ricardo de Souza Cardoso, Praveen Manivannan, Ya-Ting Chang, Eric Rentchler, Kai-Neng Chou, Yipei Tang, Joel A Swanson, Philip D King, Akira Ono

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tomoyuki MurakamiDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0002-6645-2240
Ricardo de Souza CardosoDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Praveen ManivannanDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Ya-Ting ChangDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0002-1387-3076
Eric RentchlerMicroscopy core, Biomedical Research Core Facilities, Office of Research, University of Michigan Medical School, Ann Arbor, MI 48109.
Kai-Neng ChouDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Yipei TangDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Joel A SwansonDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0003-0900-8212
Philip D KingDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0002-5598-2748
Akira OnoDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0001-7841-851X

Funding

Roles of Macropinocytosis in HIV-1 infection of CD4+ T CellsR01AI165381 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KING, PHILIP D, ONO, AKIRA · 2022 to 2025
$2.6M
NIAID NIH HHS R01 AI165381
6 · The paper itself

Abstract

HIV-1 has been observed to enter target cells at both the plasma membrane and endosomes. However, which pathways mediate its entry into primary CD4

Indexed as

CD4-Positive T-LymphocytesHIV-1PinocytosisVirus InternalizationCell MembraneEndosomesHIV InfectionsHumansHIV-1macropinocytosisprimary CD4+ T cellvirus-cell fusionvirus entry

Identifiers

PMID40465625
PMCPMC12168025

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.