Evidence map›Paper›PMID 40465510›Full record

ArticleThe veterinary quarterly2025

Longitudinal study on SARS-CoV-2 antibody responses in companion animals, Chile.

Belén Agüero, Nicole D Tischler, Raúl Alegria, Simone Cárdenas-Cáceres, Felipe Berríos, Patricio Espinoza, Nicolás A Muena, Nicolás Galarce, Galia Ramírez, Patricio Retamal and 1 more

Abstract read
In one paragraph

Article in The veterinary quarterly, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Belén AgüeroDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.ORCID 0009-0008-4202-0436
Nicole D TischlerLaboratorio de Virología Molecular, Centro Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.ORCID 0000-0002-4578-4780
Raúl AlegriaEscuela Medicina Veterinaria, Facultad de Recursos Naturales y Medicina Veterinaria, Universidad Santo Tomas, Santiago, Chile.
Simone Cárdenas-CáceresLaboratorio de Virología Molecular, Centro Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.ORCID 0009-0006-3947-8716
Felipe BerríosDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Patricio EspinozaDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Nicolás A MuenaLaboratorio de Virología Molecular, Centro Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.ORCID 0000-0003-4641-8077
Nicolás GalarceDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Galia RamírezDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Patricio RetamalDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Víctor NeiraDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.ORCID 0000-0001-9062-9969

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 infection susceptibility in dogs and cats has been documented, with identified risk factors contributing to transmission dynamics. Understanding viral prevalence and the evolution of emerging variants across pandemic waves can clarify the potential role of pets as reservoirs. This study evaluated 3298 serum samples (1921 dogs, 1377 cats) collected from 2020 to 2024. Samples were analyzed using ELISA and viral neutralization assays, revealing a positivity rate of 2.7%. We assessed neutralizing antibody titers (nAbs) against the Wuhan-Hu-1 and Omicron BA.1 strains, finding higher titers in felines compared to canines. A marked reduction in samples exceeding the detection limit was observed after November 2022. Longitudinal data from up to 30 months in a dog and 15 months in two cats demonstrated sustained antibody responses, with increased nAb titers in 7 of 14 monitored animals. Multivariable logistic regression of 275 samples indicated that a pet's vaccination status was associated with an increased risk of infection, while spring season, the owner's number of COVID-19 vaccinations, and the owner's vaccination status were protective factors. These results emphasize the significance of vaccination strategies for both human and animal health, supporting the One Health approach.

Indexed as

Antibodies, ViralCat DiseasesCOVID-19Dog DiseasesSARS-CoV-2AnimalsAntibodies, NeutralizingCatsChileDogsFemaleLongitudinal StudiesMalePetsAntibodies, NeutralizingAntibodies, Viralcatscompanion animalsCOVID-19dogsOne-HealthpandemicpetsSARS-CoV-2

Identifiers

PMID40465510
PMCPMC12138929

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.