Evidence map›Paper›PMID 40465370›Full record

ArticleJournal of cosmetic dermatology2025

Observation of Safety and Efficacy of Botulinum Toxin Type A in the Treatment of Tear Troughs and Mild Yelid Bags.

Siyuan Zhou, Homgtao Liu, Zhongjie Pan, Fuqiang Pan, Qian Liang, Houhuang Qiu, Bingliang Wu, Liming Zhang, Xiang Zhou

Abstract read
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siyuan ZhouDepartment of Medical Cosmetology, Second Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Province, China.
Homgtao LiuGuangxi Health Science College, Nanning City, Guangxi Province, China.ORCID https://orcid.org/0000-0001-5532-5599
Zhongjie PanGuangxi Medical University, Nanning City, Guangxi Province, China.
Fuqiang PanDepartment of Medical Cosmetology, Second Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Province, China.
Qian LiangDepartment of Medical Cosmetology, Second Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Province, China.
Houhuang QiuDepartment of Medical Cosmetology, Second Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Province, China.
Bingliang WuDepartment of Medical Cosmetology, Second Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Province, China.
Liming ZhangDepartment of Medical Cosmetology, Second Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Province, China.
Xiang ZhouDepartment of Medical Cosmetology, Second Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the safety and efficacy of Botulinum Toxin Type A (BTX-A) injection for the treatment of tear troughs.

methodThis study included patients with tear troughs rated as Grade 1-2 on the Barton Aesthetic Scale, who were treated between September 2023 and September 2024. These patients underwent intradermal injections of Botulinum Toxin Type A (BTX-A). Doctors conducted pre- and post-procedure assessments of the severity of tear troughs using the Barton Scale and TTRS (The Tear Trough Rating Scale). VISIA skin image analyzer (Canfield, USA) was utilized to compare the number of wrinkles, and facial scores and percentiles were calculated for objective evaluations before and after treatment. Additionally, doctors employed the Fitzpatrick Scale to assess periorbital wrinkles. This investigation was conducted as a prospective single-center study (PSS).

resultsAll 42 patients completed the study. After treatment, there was a significant improvement in VISIA-measured wrinkle count, facial scores, and percentiles. Additionally, there were significant reductions in Barton, TTRS, and Fitzpatrick scores. One case of pseudo-eyelid bags was observed post-treatment, while no other complications such as diplopia, lower eyelid skin laxity, or other adverse effects were reported.

conclusionBTX-A is effective in improving mild tear troughs while simultaneously reducing fine lines in the lower eyelid. Patients were highly satisfied with the improved appearance.

Indexed as

Botulinum Toxins, Type ACosmetic TechniquesNeuromuscular AgentsSkin AgingAdultAgedEstheticsEyelidsFemaleHumansInjections, IntradermalMaleMiddle AgedPatient SatisfactionProspective StudiesTearsBotulinum Toxins, Type ANeuromuscular Agentsbotulinum toxin type aintradermal botulinum toxin injectionnon‐surgical aesthetic treatmenttear trough

Identifiers

PMID40465370
PMCPMC12136133

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.