Evidence map›Paper›PMID 40465290›Full record

ArticleAdvanced healthcare materials2025

Concurrent Biocompatibility and Antimicrobial Functionality of Soft Diamond-Like Carbon Coating for Healthcare Applications.

Abdul Wasy Zia, Alberto Tuñón-Molina, Ioannis Anestopoulos, Miguel Martí, Iraklis-Stavros Panagiotidis, Anam Ijaz, Ángel Serrano-Aroca, Mihalis I Panayiotidis, Martin Birkett

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdul Wasy ZiaInstitute of Mechanical, Process, and Energy Engineering (IMPEE), School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4ST, UK.ORCID https://orcid.org/0000-0002-3748-4446
Alberto Tuñón-MolinaBiomaterials and Bioengineering Lab, Department of Biotechnology, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, Valencia, 46001, Spain.
Ioannis AnestopoulosDepartment of Cancer Genetics, Therapeutics and Ultrastructural Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, 1683, Cyprus.
Miguel MartíBiomaterials and Bioengineering Lab, Department of Biotechnology, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, Valencia, 46001, Spain.
Iraklis-Stavros PanagiotidisTranslational Research Centre San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Quevedo 2, Valencia, 46001, Spain.
Anam IjazInstitute of Mechanical, Process, and Energy Engineering (IMPEE), School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4ST, UK.
Ángel Serrano-ArocaBiomaterials and Bioengineering Lab, Department of Biotechnology, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, Valencia, 46001, Spain.
Mihalis I PanayiotidisDepartment of Cancer Genetics, Therapeutics and Ultrastructural Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, 1683, Cyprus.
Martin BirkettFaculty of Engineering and Environment, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.

Funding

H2020 Marie Skłodowska-Curie Actions 885534Ministerio de Ciencia e Innovación PID2020-119333RB-I00/AEI/10.13039/501100011033Universidad Católica de Valencia San Vicente Màrtir 2020-231-006UCV
6 · The paper itself

Abstract

This unprecedented study reveals the excellent antimicrobial performance of soft, hydrogen-free, pristine diamond-like carbon (DLC) coatings against life-threatening methicillin-resistant Staphylococcus aureus (MRSA). In addition, most previous studies have separately reported the biocompatibility and antimicrobial performance of DLC coatings, perhaps due to a nuance between antimicrobial performance and cytotoxicity. However, this work concurrently reports the biocompatibility of soft DLC with mouse fibroblast L929 cells and its antimicrobial performance against MRSA, where concurrent reporting is desirous for holistic material assessment, regulatory consideration, and enhanced safety and efficiency for biomedical applications. The soft DLC coatings are prepared with direct-current, open-field, magnetron sputtering, and characterized for structural, physical, mechanical, and electrical properties. The soft DLC coatings show excellent biocompatibility with 168 h leached extracts and antimicrobial performance after 24 h superior to copper, an established antimicrobial agent. This work proposes soft DLC as a safe material for concurrent biocompatibility and antimicrobial actions, as desired in most healthcare applications.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsCarbonCoated Materials, BiocompatibleDiamondMethicillin-Resistant Staphylococcus aureusAnimalsCell LineFibroblastsMaterials TestingMiceAnti-Bacterial AgentsAnti-Infective AgentsCarbonCoated Materials, BiocompatibleDiamondantimicrobialbiocompatibilitydiamond‐like carbonL929MRSAsputteringsurface coatings

Identifiers

PMID40465290
PMCPMC12304838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.