ReviewEnvironmental science and pollution research international2025
Metal mechanisms of mitochondrial toxicity: recent review of arsenic, cadmium, and lead-induced nephrotoxicity.
Review in Environmental science and pollution research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- The Role of Metals and Trace Elements in the Pathogenesis of Osteoarthritis and Other Rheumatic Diseases.International journal of molecular sciences · 2026Review
- Redox-Mediated Mitochondrial Dysfunction as a Common Pathogenic Axis in Acute Kidney Injury and Chronic Kidney Disease.Biomolecules · 2026Review
- Study on the correlation between serum lead levels and allergic rhinitis in adults and IgE levels.Medicine · 2026Article
- Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review).International journal of molecular medicine · 2026Review
- Mitochondrial Toxicology of Heavy Metals and Pesticides: Transport Systems, Mitochondrial Dysfunction and Permeability Transition.International journal of molecular sciences · 2026Review
- Capillary Electrophoresis and Atomic Absorption Spectrometry-A Rare Yet Valuable Liaison, Also from a Pharmaceutical Perspective.Molecules (Basel, Switzerland) · 2026Review
- Enhanced Renoprotective Effects of Morin-Loaded PLGA Nanoparticles Against Arsenic-Induced Kidney Injury in Rats: Amelioration of Oxidative Stress, Inflammation, Fibrosis, and Apoptosis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Cumulative Soil Metal Contamination Reshapes Oxidative and Neuroenzymatic Stress Responses in Ants Across an Industrial Pollution Gradient.Life (Basel, Switzerland) · 2026Article
- Review
- Oxidative Stress, Environmental Pollutants, Aging, and Epigenetic Regulation: Mechanistic Insights and Biomarker Advances.Antioxidants (Basel, Switzerland) · 2026Review
- Understanding molecular mechanisms driving cadmium-induced mitochondrial dysfunction in human metabolic liver disease.Environmental toxicology and pharmacology · 2026Review
- Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Environmental Pollution and Its Impact on Kidney Diseases: A Comprehensive Review of Current Evidence.Life (Basel, Switzerland) · 2026Review
- Drug-induced adverse events in modern pharmacotherapy: mechanisms, clinical manifestations, and implications for risk assessment and management.Frontiers in pharmacology · 2026Review
- Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.Journal of xenobiotics · 2025Review
- Self-activated prodrug nanocomposites reprogramming lactic acid metabolism to initiate acidosis-endoplasmic reticulum stress cascade and potentiate immunogenic cell death for enhanced liver cancer therapy.Journal of nanobiotechnology · 2025Article
- Aminoguanidine attenuates arsenic-induced hepatic oxidative stress: Dose-dependent effects in a mouse model.Toxicology reports · 2025Article
- Environmental Nephrotoxicity Across the Life Course: Oxidative Stress Mechanisms and Opportunities for Early Intervention.Antioxidants (Basel, Switzerland) · 2025Review
- Beyond glycemic control: the cardiac and hepatic benefits of SGLT2 and DPP-4 inhibitors in mitigating chronic cadmium-induced inflammation, oxidative/nitrative stress, apoptosis and fibrosis.Frontiers in physiology · 2025Article
- Effects of heavy metal exposure on kidney transplant recipients: mechanisms and clinical implications for graft failure risk.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The kidney is rich in mitochondria that are vulnerable to toxic metal injury during the filtration, secretion, and reabsorption processes required for the excretion of wastes, solutes, and xenobiotics. Understanding the mechanisms of mitochondrial toxicity of metals can provide critical insights into the mitochondrial etiology of kidney damage and the susceptible nephron segments. Recent research has revealed potential new mechanisms of mitochondrial toxicity and related adverse bioenergetic effects due to metal and metalloid exposure. Here we reviewed 20 studies on the mitotoxic effects from exposure to arsenic (n = 6), cadmium (n = 10), and lead (n = 3) as individual toxicants and as mixtures (n = 1) to gain insights into mitochondrial mechanisms of nephrotoxicity and to identify current research gaps. Studies have shown that exposure to toxic metals is associated with adverse kidney health and function with underlying changes in gene expression and enzymatic activity, loss of mitochondrial membrane potential, cellular oxidative imbalance, and inhibited electron transport. The mechanisms of damage and the severity of injury were metal and dose dependent. The proximal tubule was the most prevalent target segment of the nephron for metal-induced mitochondrial toxicity, specifically to cadmium exposure as an individual toxicant and as part of a mixture. There is a clear need to understand metal-induced mitochondrial nephrotoxicity and key research gaps that need to be filled, including the need for sex-specific and time-series studies.
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Registered trials
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