Evidence map›Paper›PMID 40465097›Full record

ReviewSpine deformity2025

Musculoskeletal biomarkers in health and disease: implications for the aging spine-a review for spinal surgeons by the SRS adult spinal deformity task force on senescence.

Tej D Azad, Marvin W Li, Chiu Ping-Yeh, Kristen E Jones, Elizabeth L Lord, Camilo A Molina, Corey T Walker, Joseph A Osorio, Javier Pizones, Alekos Theologis and 11 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Spine deformity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tej D AzadDepartment of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, USA. tazad1@jhmi.edu.ORCID http://orcid.org/0000-0001-7823-4294
Marvin W LiDepartment of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, USA.
Chiu Ping-YehDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Kristen E JonesDepartment of Neurosurgery, Duke University, Durham, NC, USA.
Elizabeth L LordDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Camilo A MolinaDepartment of Neurological Surgery, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Corey T WalkerDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Joseph A OsorioDepartment of Neurological Surgery, University of California San Diego, San Diego, CA, USA.
Javier PizonesSpine Surgery Unit, Hospital Universitario La Paz, Madrid, Spain.
Alekos TheologisDepartment of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA.
Miranda van HooffDepartment of Research, Sint Maartenskliniek, Nijmegen, The Netherlands.
Mitsuru YagiDepartment of Orthopaedic Surgery, International University of Health and Welfare, Tochigi, Japan.
Michael P KellyDepartment of Orthopaedic Surgery, University of California San Diego/Rady Children's Hospital, San Diego, CA, USA.
Marinus de KleuverDepartment of Orthopaedics, Radboud University Medical Center, Nijmegen, The Netherlands.
Serena S HuDepartment of Orthopaedic Surgery, Stanford University School of Medicine, Redwood City, CA, USA.
Suken A ShahDepartment of Orthopaedic Surgery, Alfred I. duPont Hospital for Children, Nemours Children's Clinic, Wilmington, DE, USA.
Ferran PelliséSpine Surgery Unit, Vall D'Hebron Hospital, Barcelona, Spain.
Jeremy D WalstonDepartment of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Robert K EastlackDivision of Orthopaedic Surgery, Scripps Clinic, La Jolla, CA, USA.
Christopher P AmesDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Scoliosis Research Society Adult Spinal Deformity Task Force on Senescence

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of spine-related pathologies is expected to increase in developed countries due to ongoing fundamental demographic shifts toward an older population. These changes present significant challenges to public health, as healthcare systems worldwide must confront the burden of musculoskeletal aging and its related consequences. Here, we synthesize current knowledge on the biologic mechanisms underlying musculoskeletal aging, focusing on the implications for the aging spine. The complexity of the aging process, characterized by a convoluted interplay between genetic, environmental, and lifestyle factors, necessitates a comprehensive understanding of the biologic processes and reliable methods of surveying biologic states to inform effective diagnostic, predictive, and prognostic strategies. Biomarkers emerge as invaluable tools in this domain, offering insights into the early detection, risk assessment, and targeted intervention for age-related musculoskeletal decline. This review highlights various biomarker types including diagnostic, predictive, and prognostic, and explores their distinct roles in enhancing our understanding of musculoskeletal aging. Navigating the interconnected landscape of cellular senescence, sarcopenia, osteoporosis, and frailty, this review underscores the critical importance of developing personalized care approaches for the aging population. By identifying and integrating functional biomarkers, researchers and clinicians can elucidate the underlying mechanisms and devise tailored strategies to alleviate the musculoskeletal decline associated with the aging process. We envision an "active surveillance" future where biomarkers of musculoskeletal aging are integrated into clinical practice, empowering clinicians to make proactive, data-driven decisions that improve spine health for older adults.

Indexed as

AgingBiomarkersSpineFrailtyHumansOsteoporosisPrognosisSarcopeniaBiomarkersAgingCellular senescenceFrailtyMusculoskeletal biomarkersSpine surgery

Identifiers

PMID40465097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.