Evidence map›Paper›PMID 40465093›Full record

ArticleEJNMMI research2025

Macrophage mannose receptor CD206-targeted PET imaging in experimental acute myocardial infarction.

Putri Andriana, Senthil Palani, Heidi Liljenbäck, Imran Iqbal, Vesa Oikonen, Jenni Virta, Konstantina Makrypidi, Johan Rajander, Erika Atencio Herre, Aino Suni and 7 more

Abstract read
In one paragraph

Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Immuno-positron emission tomography in cardiovascular disease: Advances, challenges, and opportunities.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026
    Review
  2. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. [ACS omega · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Putri AndrianaTurku PET Centre, University of Turku, Turku, Finland.
Senthil PalaniTurku PET Centre, University of Turku, Turku, Finland.
Heidi LiljenbäckTurku PET Centre, University of Turku, Turku, Finland.
Imran IqbalTurku PET Centre, University of Turku, Turku, Finland.
Vesa OikonenTurku PET Centre, University of Turku, Turku, Finland.
Jenni VirtaTurku PET Centre, University of Turku, Turku, Finland.
Konstantina MakrypidiInstitute of Nuclear and Radiological Science and Technology, Energy and Safety, NCSR "Demokritos", Athens, Greece.
Johan RajanderTurku PET Centre, Accelerator Laboratory, Åbo Akademi University, Turku, Finland.
Erika Atencio HerreTurku PET Centre, University of Turku, Turku, Finland.
Aino SuniTurku PET Centre, University of Turku, Turku, Finland.
Sirpa JalkanenMediCity Research Laboratory, University of Turku, Turku, Finland.
Juhani KnuutiTurku PET Centre, University of Turku, Turku, Finland.
Luisa Martinez-PomaresSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Ioannis PirmettisInstitute of Nuclear and Radiological Science and Technology, Energy and Safety, NCSR "Demokritos", Athens, Greece.
Xiang-Guo LiTurku PET Centre, University of Turku, Turku, Finland.
Antti SarasteTurku PET Centre, University of Turku, Turku, Finland.
Anne RoivainenTurku PET Centre, University of Turku, Turku, Finland. anne.roivainen@utu.fi.ORCID http://orcid.org/0000-0002-4006-7977

Funding

Academy of Finland 350117
6 · The paper itself

Abstract

backgroundThe macrophage mannose receptor (CD206) is expressed predominantly on the surface of M2-type macrophages, which play a role in resolution of inflammation after myocardial injury. The purpose of this study was to evaluate the utility of CD206-targeted PET tracer Al[

resultsFlow cytometry revealed selective binding of Alexa-488-NOTA-D10CM to human M2-polarized macrophages derived from blood monocytes compared to M1 macrophages. The binding affinity of Al[

conclusionAl[

Indexed as

CD206InflammationMacrophage mannose receptorMyocardial infarctionPET

Identifiers

PMID40465093
PMCPMC12137864

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.