Evidence map›Paper›PMID 40465059›Full record

ArticleMolecular biology reports2025

Argyreia nervosa (Brum.f.) Bojer. alleviates diabetes mellitus-induced male infertility.

Pooja Veljibhai Gori, Manan Raval, Samir Patel, Amit Patel, Nilay Solanki, Priyal Patel, Manish Nandpal, Palash Mandal, Hiral Aghara

Abstract read
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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pooja Veljibhai GoriDepartment of Pharmacology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand,, Changa, Gujarat, 388421, India.
Manan RavalDepartment of Pharmacognosy and Phytochemistry, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand, Changa, Gujarat, 388421, India. mananraval.ph@charusat.ac.in.ORCID https://orcid.org/0000-0002-5823-2264
Samir PatelDepartment of Pharmaceutical Chemistry and Analysis, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand,, Changa, Gujarat, 388421, India.
Amit PatelDepartment of Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand,, Changa, Gujarat, 388421, India.
Nilay SolankiDepartment of Pharmacology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand,, Changa, Gujarat, 388421, India.
Priyal PatelDepartment of Pharmacology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand,, Changa, Gujarat, 388421, India.
Manish NandpalDepartment of Pharmaceutical Chemistry and Analysis, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand,, Changa, Gujarat, 388421, India.
Palash MandalDepartment of Biological Science, P.D. Patel Institute of Applied Science, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand,, Changa, Gujarat, 388421, India.
Hiral AgharaDepartment of Biological Science, P.D. Patel Institute of Applied Science, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, At and Post: Dist. Anand,, Changa, Gujarat, 388421, India.

Funding

Gujarat Knowledge Society/ Student Startup Innovation Policy/ Student Open Innovation Challenge SOIC2021-00L708Knowledge Consortium of Gujarat SODH Scholarship 202001300014
6 · The paper itself

Abstract

backgroundDiabetes Mellitus (DM) impairs male reproductive functions by modulating apoptosis, oxidation, and the inflammatory pathway. The studies were planned to screen the ability of the hydro-alcoholic extract (AN) prepared using the roots of Argyreia nervosa (A. nervosa) (Burm.Fil.) Bojer. (Family: Convolvulaceae) in alleviating the DM-induced detrimental functioning of male reproductive functions in experimental rats. METHOD AND

resultsDiabetic conditions were induced by the combined administration of a high-fat diet and a single injection of streptozotocin (30 mg/kg). Diabetic rats treated with a higher dose of A. nervosa extract (ANH) showed decreased fasting blood glucose (0.52-fold), abnormal sperm morphology (0.50-fold), and sperm DNA fragmentation index (0.74-fold), along with improved semen quality. ANH increased testicular testosterone (1.40-fold), FSH (1.91-fold), LH (1.69-fold), and mRNA expression of StAR (1.75-fold), 17β-HSD (1.77-fold), and 3β-HSD (1.06-fold). It reduced MDA (0.72-fold) and raised SOD (1.93-fold) and GSH (2.13-fold). ANH also lowered mRNA/protein levels of RAGE (0.75-fold, 8.81-fold), TNF-α (0.79-fold, 2.11-fold), NLRP3 (0.68-fold, 8.15-fold), and Caspase-3 (0.87-fold, 8.45-fold).

conclusionAN, thus, showed the potential beneficial effects on DM-induced male infertility, probably through its ability to counter DM induced apoptosis and inflammation in testicular tissues along with supporting anti-oxidant mechanisms. The extract could upregulate testosterone biosynthesis by modulating steroidogenic enzyme activity and stimulating FSH and LH levels. This action further supported the improvement of sperm functioning parameters in diabetic rats. These results provided the potential of AN as an alternative treatment for the clinical management of DM-impaired male reproductive function, offering hope for future research and clinical applications.

Indexed as

Diabetes Mellitus, ExperimentalInfertility, MalePlant ExtractsAnimalsApoptosisBlood GlucoseDNA FragmentationFollicle Stimulating HormoneMaleOxidative StressRatsSemen AnalysisSpermatozoaTestisTestosteroneBlood GlucoseFollicle Stimulating HormonePlant ExtractsTestosteroneAntioxidant propertiesDiabetes mellitusMale reproductive healthPhytotherapyTesticular dysfunction

Identifiers

PMID40465059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.