Evidence map›Paper›PMID 40465027›Full record

ArticleCardiovascular toxicology2025

LncRNA AK020546 Alleviates Myocardial Ischemia-Reperfusion Injury via Suppressing METTL14/m6A/MST1 Axis-Mediated Ferroptosis.

Meiqi Zhang, Qilan Chen, Jie Chen, Yun Chen, Wei Zhang, Yakun Wang, Limei Yu, Zhenfei Yu

Abstract read
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In one paragraph

Article in Cardiovascular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meiqi ZhangDepartment of Intensive Care Unit, Hangzhou Hospital Of Traditional Chinese Medicine (Dingqiao District), No.453 Tiyuchang Road, Hangzhou, 310013, Zhejiang, China.
Qilan ChenDepartment of Intensive Care Unit, Hangzhou Hospital Of Traditional Chinese Medicine (Dingqiao District), No.453 Tiyuchang Road, Hangzhou, 310013, Zhejiang, China.
Jie ChenDepartment of Intensive Care Unit, Hangzhou Hospital Of Traditional Chinese Medicine (Dingqiao District), No.453 Tiyuchang Road, Hangzhou, 310013, Zhejiang, China.
Yun ChenDepartment of Intensive Care Unit, Hangzhou Hospital Of Traditional Chinese Medicine (Dingqiao District), No.453 Tiyuchang Road, Hangzhou, 310013, Zhejiang, China.
Wei ZhangDepartment of Intensive Care Unit, Hangzhou Hospital Of Traditional Chinese Medicine (Dingqiao District), No.453 Tiyuchang Road, Hangzhou, 310013, Zhejiang, China.
Yakun WangDepartment of Intensive Care Unit, Hangzhou Hospital Of Traditional Chinese Medicine (Dingqiao District), No.453 Tiyuchang Road, Hangzhou, 310013, Zhejiang, China.
Limei YuDepartment of Intensive Care Unit, Hangzhou Hospital Of Traditional Chinese Medicine (Dingqiao District), No.453 Tiyuchang Road, Hangzhou, 310013, Zhejiang, China.
Zhenfei YuDepartment of Intensive Care Unit, Hangzhou Hospital Of Traditional Chinese Medicine (Dingqiao District), No.453 Tiyuchang Road, Hangzhou, 310013, Zhejiang, China. dr.yuzhenfei@outlook.com.

Funding

Zhejiang Health Science and Technology Program 2020KY749
6 · The paper itself

Abstract

Ferroptosis occurs after myocardial ischemia-reperfusion (I/R) injury. Long non-coding RNA (lncRNA) AK020546 possesses the effect of protecting the myocardium from I/R injury; however, the underlying mechanisms remain not fully understood. This study aimed to investigate the effect of AK020546 on ferroptosis in cardiomyocytes and underlying molecular mechanisms. Hypoxia/reoxygenation (H/R) was used to induce H9C2 injury, and an I/R rat model was generated. Ferroptosis was evaluated by detecting lipid reactive oxygen species, Fe

Indexed as

AdenosineFerroptosisHepatocyte Growth FactorMethyltransferasesMyocardial Reperfusion InjuryMyocytes, CardiacProto-Oncogene ProteinsRNA, Long NoncodingAnimalsCell LineDisease Models, AnimalMaleMethylationRatsRats, Sprague-DawleySignal TransductionAdenosineHepatocyte Growth Factormacrophage stimulating proteinMethyltransferasesN-methyladenosineProto-Oncogene ProteinsRNA, Long NoncodingAK020546Ferroptosism6A methylationMETTL14Mst1

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.