Evidence map›Paper›PMID 40464993›Full record

ArticleBulletin of mathematical biology2025

Spatio-Temporal Dynamics of M

Ioannis Lampropoulos, Panayotis G Kevrekidis, Christos E Zois, Helen Byrne, Michail Kavousanakis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bulletin of mathematical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ioannis LampropoulosSchool of Chemical Engineering, National Technical University of Athens, Iroon Polytechneiou 9, Zografou, Athens, 15780, Greece.
Panayotis G KevrekidisDepartment of Mathematics and Statistics and Department of Physics, University of Massachusetts Amherst, Amherst, 01003, Massachusetts, United States of America.
Christos E ZoisDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, England.
Helen ByrneMathematical Institute, University of Oxford, Wellington Square, Oxford, OX1 2JD, England.
Michail KavousanakisSchool of Chemical Engineering, National Technical University of Athens, Iroon Polytechneiou 9, Zografou, Athens, 15780, Greece. mihkavus@chemeng.ntua.gr.ORCID http://orcid.org/0000-0001-6621-9249

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the complex dynamics of vascular tumors and their interplay with macrophages, key agents of the innate immune response. We model the tumor microenvironment as a multiphase fluid, with each cellular population treated as a distinct, non-mixing phase. The framework also incorporates diffusible species that are critical for processes such as nutrient transport, angiogenesis, chemotaxis, and macrophage activation. A central contribution of this work is the explicit modeling of macrophage infiltration and polarization within the tumor microenvironment. The model captures the divergent roles of

Indexed as

MacrophagesModels, BiologicalNeoplasmsAnimalsComputer SimulationHumansImmunity, InnateImmunotherapyMacrophage ActivationMathematical ConceptsNeovascularization, PathologicSpatio-Temporal AnalysisTransforming Growth Factor betaTumor-Associated MacrophagesTumor MicroenvironmentTransforming Growth Factor betaImmunotherapyMultiphase model

Identifiers

PMID40464993
PMCPMC12137437

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.