Evidence map›Paper›PMID 40464944›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Induction of potent preferential cell death, severe DNA damage and p53-independent ROS-mediated mitochondrial apoptosis by CaTiO

Hanan R H Mohamed, Maivel Michael, Yusuf Elberry, Hagar Magdy, Maryam Ismail, Nourhan Eltayeb, Gehan Safwat, Ayman Diab

Abstract read
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanan R H MohamedDepartment of Zoology, Faculty of Science, Cairo University, Giza, Egypt. hananeeyra@cu.edu.eg.
Maivel MichaelFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6 Th of October City, Egypt.
Yusuf ElberryFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6 Th of October City, Egypt.
Hagar MagdyFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6 Th of October City, Egypt.
Maryam IsmailFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6 Th of October City, Egypt.
Nourhan EltayebFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6 Th of October City, Egypt.
Gehan SafwatFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6 Th of October City, Egypt.
Ayman DiabFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6 Th of October City, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aggressive nature and high recurrence rate of tongue cancer, along with the severe side effects associated with current conventional treatments, underscore the urgent need for alternative therapeutic strategies that offer improved selectivity and reduced toxicity. Calcium titanate nanoparticles (CaTiO

Indexed as

Antineoplastic AgentsApoptosisMetal NanoparticlesMitochondriaReactive Oxygen SpeciesTitaniumTongue NeoplasmsCell Line, TumorCell SurvivalDNA DamageHumansTumor Suppressor Protein p53Antineoplastic AgentsReactive Oxygen SpeciesTitaniumTP53 protein, humanTumor Suppressor Protein p53CaTiO3NPsGenomic instabilityHNO-97 tongue cellsMitochondrial dysfunction and apoptosis inductionROS generationSRB assay

Identifiers

PMID40464944
PMCPMC12678538

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.