Evidence map›Paper›PMID 40464914›Full record

ArticleEuropean radiology2025

Prognostic impact of remote myocardium changes using T1 mapping in patients with ST-segment elevation myocardial infarction.

Fritz Oberhollenzer, Ivan Lechner, Martin Reindl, Christina Tiller, Magdalena Holzknecht, Franziska Roithinger, Can Gollmann-Tepeköylü, Agnes Mayr, Axel Bauer, Bernhard Metzler and 1 more

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Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fritz OberhollenzerUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Ivan LechnerUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Martin ReindlUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Christina TillerUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Magdalena HolzknechtUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Franziska RoithingerUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Can Gollmann-TepeköylüUniversity Clinic of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Agnes MayrUniversity Clinic of Radiology, Medical University of Innsbruck, Innsbruck, Austria.
Axel BauerUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Bernhard MetzlerUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Sebastian J ReinstadlerUniversity Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria. Sebastian.Reinstadler@gmail.com.ORCID http://orcid.org/0000-0002-7700-1357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the prognostic relevance of remote myocardium alterations assessed by cardiac magnetic resonance (CMR) T1 mapping (native T1 and extracellular volume (ECV)) in patients after ST-segment elevation myocardial infarction (STEMI). MATERIALS AND

methodsThis retrospective study analyzed STEMI patients treated with primary percutaneous coronary intervention (PCI) who were included in the prospective MARINA-STEMI study. CMR images were analyzed for left ventricular (LV) function, standard infarct characteristics, as well as native remote T1 and remote ECV. The primary clinical endpoint was the composite of all-cause mortality, re-infarction and new congestive heart failure (Major adverse cardiac events (MACE)).

resultsFour hundred ninety-one patients (median age 58 [Interquartile range (IQR): 52-66 years], 91 (19%) female) patients underwent CMR imaging at 4 ([IQR: 3-5]) days after PCI. Over a median follow-up of 12 months ([IQR: 12-13]) after STEMI, 42 MACE outcomes occurred. Higher native remote T1-times (1018.5 [IQR: 997.0-1064.0] ms vs. 1007.0 [IQR: 977.0-1041.5] ms, p = 0.033) as well as higher remote ECV values (28.07 vs. 26.27%, p = 0.009) were observed in patients with MACE. Multivariable Cox-regression analysis demonstrated that remote ECV (hazard ratio (HR): 1.53 [confidence interval (CI): 1.07-2.19], p = 0.020) but not native remote T1 is independently associated with MACE.

conclusionsA comprehensive assessment of the remote myocardium with native T1 and ECV provides prognostic information in a contemporary cohort of low-risk STEMI patients. Remote ECV, but not remote native T1, was found to be an independent predictor of MACE. KEY POINTS: Question The prognostic implications of remote myocardium changes assessed by cardiac magnetic resonance (CMR) T1 mapping in patients after ST-segment elevation myocardial infarction (STEMI) are not fully understood. Findings After STEMI, for patients treated with primary percutaneous coronary intervention, remote extracellular volume (ECV) was found to be an independent predictor of major adverse cardiac events. Clinical relevance This study underlines the importance of remote myocardium characterization as a promising diagnostic tool. In particular, the quantification of ECV changes in the remote myocardium could be relevant for optimized CMR-imaging-based risk stratification in patients after STEMI.

Indexed as

Magnetic Resonance ImagingMagnetic Resonance Imaging, CineMyocardiumST Elevation Myocardial InfarctionAgedFemaleHumansMaleMiddle AgedPercutaneous Coronary InterventionPrognosisRetrospective StudiesExtracellular volumeMajor adverse cardiac eventsST-segment elevation myocardial infarction, Magnetic resonance imagingT1 mapping

Identifiers

PMID40464914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.