Evidence map›Paper›PMID 40464874›Full record

ArticleCEN case reports2025

A rare case of coronin-1A deficiency with IgM dominant membranoproliferative glomerulonephritis.

Zeynep Ural, Betül Ogüt, Gülsüm Kayhan, Ipek Işık Gönül, Ulver Derici

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PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zeynep UralDepartment of Nephrology, Kırıkkale Yüksek Ihtisas Hospital, Kırıkkale, Turkey. zeynepkaracan14@gmail.com.ORCID 0000-0002-3162-8760
Betül OgütDepartment of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Gülsüm KayhanDepartment of Medical Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ipek Işık GönülDepartment of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ulver DericiDepartment of Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronin-1A deficiency, caused by mutations in the CORO1A gene, is an autosomal recessive immunodeficiency characterized by T-cell dysfunction and is classified as severe combined immunodeficiency (SCID). This condition presents with lymphopenia, hypogammaglobulinemia, recurrent Epstein-Barr virus (EBV) infections, EBV-associated B-cell lymphoma and epidermodysplasia verruciformis. This case report presents a 32-year-old female with Coronin-1A deficiency, who developed IgM-dominant membranoproliferative glomerulonephritis (MPGN) alongside recurrent viral infections. This is the first reported case linking Coronin-1A deficiency with MPGN. The patient was treated with corticosteroids, which improved her renal function, but she succumbed to recurrent infections within a year. This case emphasizes the potential for renal disease in immunodeficient patients with persistent infections.

Indexed as

Glomerulonephritis, MembranoproliferativeImmunoglobulin MMicrofilament ProteinsAdrenal Cortex HormonesAdultFatal OutcomeFemaleHumansAdrenal Cortex Hormonescoronin proteinsImmunoglobulin MMicrofilament ProteinsCoronin-1A deficiencyImmunodeficiencyMembranoproliferative glomerulonephritis

Identifiers

PMID40464874
PMCPMC12457232

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