ArticleAesthetic plastic surgery2025
The Comparative Study of the Effects of Botulinum Toxin Micro-droplet Injection Combined with Micro-crosslinked Sodium Hyaluronate Gel or Focused Ultrasound Technology in Facial Rejuvenation Treatment.
Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Tripartite Regulatory Framework of the Skin Extracellular Microenvironment and Related Anti-aging Strategies.Mini reviews in medicinal chemistry · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe harmonization of micro-droplet botulinum toxin injections with either micro-crosslinked sodium hyaluronate gel or focused ultrasound technology necessitating a comprehensive evaluation of their differential impact.
methodsA retrospective analysis of clinical data was conducted on 114 patients who underwent facial rejuvenation treatment. The patients were divided into two groups: one receiving botulinum toxin micro-droplet injection combined with micro-crosslinked hyaluronic acid sodium gel (n=56) and the other receiving botulinum toxin micro-droplet injection combined with focused ultrasound technology (n=58). The study assessed baseline characteristics, procedural aspects, recovery, side effects, facial laxity and rejuvenation (FLR), and quality of life using validated rating scales and criteria.
resultsThe study revealed several significant findings. The procedural duration was shorter in the micro-crosslinked sodium hyaluronate gel group, whereas the time to return to normal activities was shorter in the focused ultrasound group. The incidence of edema and erythema was significantly lower in the focused ultrasound group. FLR scale scores showed better skin elasticity and tightness in the focused ultrasound group, while quality of life scores indicated variations in emotion management and return to social function between the two groups.
conclusionThe study emphasizes the multifaceted impact of botulinum toxin micro-droplet injection combined with micro-crosslinked sodium hyaluronate gel and focused ultrasound technology on various parameters in facial rejuvenation treatment. These findings provide valuable insights into the differential effects of these treatment modalities, highlighting the need for personalized approaches and patient-centered care in cosmetic dermatology and plastic surgery. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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