Evidence map›Paper›PMID 40464805›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Diagnosis of treatment-related changes in children and adolescents with brain and spinal tumors: a cost-effectiveness analysis using MRI and [18 F]FET PET.

Jurij Rosen, Jan-Michael Werner, Garry S Ceccon, Elena K Rosen, Michael M Wollring, Isabelle Stetter, Philipp Lohmann, Felix M Mottaghy, Lisbeth Marner, Ian Law and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Advances in the management of pediatric low-grade glioma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  2. Clinical Utility of [AJNR. American journal of neuroradiology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jurij RosenDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Jan-Michael WernerDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937, Cologne, Germany.
Garry S CecconDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937, Cologne, Germany.
Elena K RosenDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937, Cologne, Germany.
Michael M WollringDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937, Cologne, Germany.
Isabelle StetterDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937, Cologne, Germany.
Philipp LohmannResearch Center Juelich, Institute of Neuroscience and Medicine (INM-3, INM-4), Leo-Brandt-St. 5, 52425, Juelich, Germany.
Felix M MottaghyDepartment of Nuclear Medicine, RWTH University Hospital Aachen, Aachen, Germany.
Lisbeth MarnerDepartment of Clinical Physiology Nuclear Medicine and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Ian LawDepartment of Clinical Physiology Nuclear Medicine and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Gereon R FinkDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937, Cologne, Germany.
Karl-Josef LangenResearch Center Juelich, Institute of Neuroscience and Medicine (INM-3, INM-4), Leo-Brandt-St. 5, 52425, Juelich, Germany.
Norbert GalldiksDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937, Cologne, Germany. n.galldiks@fz-juelich.de.ORCID 0000-0002-2485-1796

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePET using the radiolabeled amino acid O-(2-[

methodsWe analyzed clinical data from two different studies that assessed the value of FET PET to differentiate between brain and spinal tumor relapse and treatment-related changes in children and adolescents. Cost calculation was based on the German statutory health insurance system perspective. Due to subtle differences in the diagnostic approach of the studies, two separate clinical scenarios including 80 patients with 105 lesions were considered: Decision tree model 1 determined cost-effectiveness of simultaneous [

resultsModel 1 revealed that the rate of identified treatment-related changes increased by 52% when adding [

conclusionIntegrating [

Indexed as

Brain NeoplasmsMagnetic Resonance ImagingPositron-Emission TomographySpinal NeoplasmsTyrosineAdolescentChildChild, PreschoolCost-Benefit AnalysisCost-Effectiveness AnalysisDecision TreesFemaleHumansMale(18F)fluoroethyltyrosineTyrosineAmino acid PETEconomic evaluationTreatment monitoringTumor relapse

Identifiers

PMID40464805
PMCPMC12491346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.