Evidence map›Paper›PMID 40464581›Full record

ArticleJournal of virology2025

Trim7 does not have a role in the restriction of murine norovirus infection

Mridula Annaswamy Srinivas, Linley R Pierce, Mikayla C Olson, Shelly J Roberston, Gail L Sturdevant, Sonja M Best, Robert C Orchard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Mridula Annaswamy SrinivasDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Linley R PierceDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mikayla C OlsonLaboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Shelly J RoberstonLaboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Gail L SturdevantLaboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Sonja M BestLaboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Robert C OrchardDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-8216-4946

Funding

The Role of Trim Proteins in Regulating Norovirus Replication and TropismR01DK133231 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Robert C. Orchard · 2023 to 2026
$1.9M
NIDDK NIH HHS R01 DK133231NIH HHS 5R01DK133231
6 · The paper itself

Abstract

Trim7 is an E3 ubiquitin ligase that was recently identified as a central regulator of host-viral interactions with both pro-viral and anti-viral activity in cell culture. As an inhibitor, Trim7 overexpression ubiquitinates viral proteins by recognizing C-terminal glutamines that are hallmarks of 3C-like protease cleavage events. Here, we sought to determine the physiological impact of Trim7 in resolving murine norovirus (MNV) infection of mice, as MNV is potently inhibited by Trim7

Indexed as

Caliciviridae InfectionsNorovirusTripartite Motif ProteinsUbiquitin-Protein LigasesAnimalsDisease Models, AnimalHost-Pathogen InteractionsImmunity, InnateMiceMice, Inbred C57BLMice, KnockoutVirus ReplicationTripartite Motif ProteinsUbiquitin-Protein Ligasesmurine norovirusnorovirusTrim7

Identifiers

PMID40464581
PMCPMC12282188

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.