Evidence map›Paper›PMID 40464579›Full record

ArticleJournal of virology2025

SARS-CoV-2 infection enhancement by amphotericin B: implications for disease management.

Dung Nguyen, Stephen M Laidlaw, Xiaofeng Dong, Matthew Wand, Amanda Horton, Mark Sutton, Julia Tree, Rachel Milligan, Maximillian Erdmann, David Matthews and 4 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dung NguyenCentre for Human Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-9390-9990
Stephen M LaidlawCentre for Human Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7970-6174
Xiaofeng DongInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Matthew WandUK Health Security Agency, London, United Kingdom.
Amanda HortonUK Health Security Agency, London, United Kingdom.
Mark SuttonUK Health Security Agency, London, United Kingdom.
Julia TreeUK Health Security Agency, London, United Kingdom.
Rachel MilliganSchool of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University Walk, University of Bristol, Bristol, United Kingdom.
Maximillian ErdmannSchool of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University Walk, University of Bristol, Bristol, United Kingdom.
David MatthewsSchool of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University Walk, University of Bristol, Bristol, United Kingdom.
Andrew D DavidsonSchool of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University Walk, University of Bristol, Bristol, United Kingdom.
Khondaker Miraz RahmanInstitute of Pharmaceutical Science, King's College London, London, United Kingdom.ORCID 0000-0001-8566-8648
Julian A HiscoxInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-6582-0275
Miles CarrollCentre for Human Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7026-7187

Funding

U.S. Food and Drug Administration 75F40120C00085
6 · The paper itself

Abstract

Severe coronavirus disease 2019 (COVID-19) patients who require hospitalization are at high risk of invasive pulmonary mucormycosis. Amphotericin B (AmB), which is the first-line therapy for invasive pulmonary mucormycosis, has been shown to promote or inhibit replication of a spectrum of viruses. In this study, we first predicted that AmB and nystatin had strong interactions with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins using

Indexed as

Amphotericin BAntifungal AgentsSARS-CoV-2AnimalsAntiviral AgentsCell LineChlorocebus aethiopsCOVID-19COVID-19 Drug TreatmentHumansNystatinVero CellsVirus ReplicationAmphotericin BAntifungal AgentsAntiviral AgentsNystatinamphotericin Bdisease managementinfection enhancementSARS-CoV-2

Identifiers

PMID40464579
PMCPMC12282131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.