Evidence map›Paper›PMID 40464345›Full record

ArticleJournal of medicinal chemistry2025

Uncovering the Unusual Inhibition Mechanism of a Trypanosome Alternative Oxidase Inhibitor Displaying Broad-Spectrum Activity against African Animal Trypanosomes.

Godwin U Ebiloma, Emmanuel O Balogun, Natsumi Arai, Momoka Otani, Cecilia Baldassarri, Amani Alhejely, Eduardo Cueto-Díaz, Harry P De Koning, Christophe Dardonville, Tomoo Shiba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Godwin U EbilomaSchool of Science, Engineering & Environment, University of Salford, Manchester M5 4NT, United Kingdom.ORCID 0000-0003-4072-9800
Emmanuel O BalogunDepartment of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria.ORCID 0000-0002-2092-0045
Natsumi AraiGraduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
Momoka OtaniGraduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
Cecilia BaldassarriMedicinal Chemistry Unit, School of Pharmacy, Chemistry Interdisciplinary Project (ChIP), University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy.
Amani AlhejelyBiology Department, Darb University College, Jazan University, Jazan 82817-2820, Saudi Arabia.
Eduardo Cueto-DíazInstituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain.ORCID 0000-0002-3893-3987
Harry P De KoningSchool of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G43 2DX, United Kingdom.ORCID 0000-0002-9963-1827
Christophe DardonvilleInstituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain.ORCID 0000-0001-5395-1932
Tomoo ShibaGraduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.

Funding

Multi-target approach to rational design of novel therapeutics for human African trypanosomiasisK43TW012015 · FIC · AHMADU BELLO UNIVERSITY · PI BALOGUN, EMMANUEL OLUWADARE · 2021 to 2025
$577k
FIC NIH HHS K43 TW012015
6 · The paper itself

Abstract

The glucose-dependent respiration of bloodstream forms of the parasite

Indexed as

Enzyme InhibitorsMitochondrial ProteinsOxidoreductasesPlant ProteinsTrypanocidal AgentsTrypanosomaTrypanosomiasis, AfricanAlternative OxidaseAnimalsCrystallography, X-RayMiceModels, MolecularProtozoan ProteinsStructure-Activity RelationshipAlternative OxidaseEnzyme InhibitorsMitochondrial ProteinsOxidoreductasesPlant ProteinsProtozoan ProteinsTrypanocidal Agents

Identifiers

PMID40464345
PMCPMC12406258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.