Evidence map›Paper›PMID 40464292›Full record

ReviewOrthodontics & craniofacial research2025

Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception.

Brian Edwin Cairns

Abstract readReview
In one paragraph

Review in Orthodontics & craniofacial research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Brian Edwin CairnsFaculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-6937-5690

Funding

Natural Sciences and Engineering Research Council of Canada
6 · The paper itself

Abstract

Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial tissues and the trigeminal ganglion. Research articles were identified using PubMed with the mesh terms adrenergic, ganglion neuron, masseter, sensory, signaling, temporomandibular and trigeminal and, subsequently, from the reference lists of those articles identified. The masticatory muscles and temporomandibular joint are innervated by sympathetic efferent fibres from the superior cervical ganglion, which primarily innervates blood vessels. As trigeminal sensory afferent fibres are often found near blood vessels, the anatomical relationship for potential sympathetic sensory coupling is present in the temporomandibular joint and masticatory muscles. Trigeminal afferent fibres express α

Indexed as

Facial PainNociceptionSympathetic Nervous SystemTemporomandibular JointTemporomandibular Joint DisordersHumansMasticatory MusclesNociceptorsTrigeminal Ganglionadrenergicmasticatorypainsensorytemporomandibular

Identifiers

PMID40464292
PMCPMC12927135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.