Evidence map›Paper›PMID 40464272›Full record

ArticleCNS neuroscience & therapeutics2025

Whole Brain Monosynaptic Input of Distinct Neurons in the Globus Pallidus Externa.

Ming-Feng Ma, Jie Hu, Ya-Xin Hao, Kai-Ying Zhang, Xiang Zhang, Meng-Chu Zhu, Zong-Lei Zhou, Xiang-Shan Yuan, Fang Yuan

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Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ming-Feng MaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.ORCID 0009-0001-2792-9499
Jie HuSchool of Nursing, Hebei Medical University, Shijiazhuang, Hebei, China.
Ya-Xin HaoDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.
Kai-Ying ZhangDepartment of Anatomy and Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xiang ZhangDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.
Meng-Chu ZhuDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.
Zong-Lei ZhouCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.ORCID 0000-0001-7248-409X
Xiang-Shan YuanDepartment of Anatomy and Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID 0000-0003-2365-8756
Fang YuanDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.ORCID 0000-0002-2590-1572

Funding

Hebei Province Central Guidance Fund for Local Scientific and Technological Development Basic Research Project 216Z7712GHebei Province Yanzhao Golden Platform Project HJZD202510National Natural Science Foundation of China 31971110National Natural Science Foundation of China 32171142National Natural Science Foundation of China 32371192National Natural Science Foundation of China 82170104
6 · The paper itself

Abstract

objectiveThe globus pallidus externa (GPe) is involved in mediating physiological functions and contains two types of neurons: Forkhead box protein P2-expressing (GPe

methodsIn this study, we employed specific, modified rabies viruses and adeno-associated viruses to investigate the monosynaptic inputs of GPe

resultsWe found that the input projections to both types of neurons are widespread, including the cortex, subcortical structures, amygdala, thalamus, hypothalamus, and brainstem. These inputs exhibit significant similarity, with 49 nuclei simultaneously innervating both types of neurons. However, GPe

conclusionCollectively, our results reveal the similarities and differences in the input projections to the two types of neurons in the GPe and lay the neuroanatomic groundwork for further studies to explore the critical physiological functions of GPe.

Indexed as

Globus PallidusNeuronsSynapsesAnimalsDependovirusMaleMiceMice, TransgenicNeural PathwaysParvalbuminsRabies virusParvalbuminsafferent inputsFoxP2globus pallidus externaPV

Identifiers

PMID40464272
PMCPMC12134940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.