Evidence map›Paper›PMID 40464260›Full record

ArticleAnalytical chemistry2025

Quantitative Determination of Click-Reactive Antisense Oligonucleotide and Its Reactivity in Rat Brains by Hybridization LC-MS/MS to Support Pretargeted PET Imaging.

Di Jiang, Brendon E Cook, Thomas Pickel, Long Yuan

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Di JiangDrug Metabolism and Pharmacokinetics, Biogen, 225 Binney St, Cambridge, Massachusetts 02142, United States.
Brendon E CookTranslational Sciences, Biogen, 225 Binney St, Cambridge, Massachusetts 02142, United States.ORCID 0000-0002-7560-5739
Thomas PickelTechnical Development, Biogen, 5000 Davis Drive, Research Triangle Park, North Carolina 27709, United States.
Long YuanDrug Metabolism and Pharmacokinetics, Biogen, 225 Binney St, Cambridge, Massachusetts 02142, United States.ORCID 0000-0003-1863-2308

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antisense oligonucleotide (ASO) therapeutics are rapidly increasing in prevalence for the treatment of neurodegenerative diseases. A novel pretargeted positron emission tomography (PET) imaging methodology based on

Indexed as

BrainOligonucleotides, AntisensePositron-Emission TomographyAnimalsChromatography, LiquidClick ChemistryLiquid Chromatography-Mass SpectrometryMaleRatsRats, Sprague-DawleyTandem Mass SpectrometryTissue DistributionOligonucleotides, Antisense

Identifiers

PMID40464260
PMCPMC12177869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.