ArticleJournal of cachexia, sarcopenia and muscle2025
Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention.BMC medicine · 2026Observational
- Triglyceride-glucose index is associated with cerebral small vessel disease-related motor impairment in Parkinson's disease: a mediation analysis.Frontiers in aging neuroscience · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhite matter hyperintensity (WMH) is one of the key imaging markers of cerebral small vessel disease (CSVD) and white matter microstructural injury may occur earlier than WMH. However, the associations of handgrip strength (HGS) and serum total testosterone (STT) with WMH and microstructural injury have not been thoroughly investigated. Therefore, we aimed to explore the associations of HGS and STT with WMH and microstructural injury, measured by fractional anisotropy (FA), mean diffusivity (MD), intracellular volume fraction (ICVF), and isotropic volume fraction (ISOVF).
methodsA total of 34 832 participants from the UK Biobank (aged 64.15 ± 7.75 years, 50.9% male) were included in the study. Cross-sectional analyses were conducted using three linear regression models to assess the relationships between HGS, STT and neuroimaging outcomes. Sensitivity analyses were performed to validate the robustness of the linear regression results. Longitudinal, mediation and Mendelian randomization (MR) analyses were conducted to explore the longitudinal impact of HGS on WMH, the mediating effects of STT between HGS and neuroimaging outcomes, and probable causal relationships between HGS, STT and WMH.
resultsA greater HGS was linearly associated with a smaller WMH volume (β = -0.006642, p < 0.001) and fuller microstructure (p < 0.001). These relationships persisted when stratified by sex or age decade and were supported by the results of the longitudinal analysis (β = -26.4, p = 0.0145). In females, STT was found to be linearly negatively related to WMH volume (β = -0.109, p < 0.001), MD and ISOVF, and linearly positively related to FA and ICVF (p < 0.001). In males, STT was linearly negatively linked to WMH volume (β = -0.016, p < 0.001) and MD (β = -1.6
conclusionsOur study revealed that greater HGS was linearly associated with reduced WMH volume and less white matter microstructural injury, mediated by STT. Improving muscle function may contribute to deferring white matter damage and preventing stroke and dementia, offering a feasible secondary prevention measure for CSVD.
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