ArticleJournal of cachexia, sarcopenia and muscle2025
Moderation Effect of Handgrip Strength on Cognition and Functional Independence Associations in Adults Over 90 Years.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Intraday and Interday Reliability of Maximal and Explosive Handgrip Force-Time Metrics Using the Kinvent K-Grip Handheld Dynamometer.Muscles (Basel, Switzerland) · 2026Article
- Physical function versus cognitive status: Which better predicts independence in basic activities among long-lived cognitively preserved older adults.Australasian journal on ageing · 2025Article
- Dietary B-complex vitamins and sleep quality in relation to cognitive impairment among older adults: non-linear associations and evidence of additive interaction.Frontiers in nutrition · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
introductionThe causal relationship between cognitive impairment and functional decline seems bidirectional in older adults. This study aimed to determine the moderating effect of handgrip strength on the relationship between cognition and functional independence among Brazilian nonagenarians and centenarians.
methodsA cross-sectional study was performed on 150 older adults aged > 90 years (141 nonagenarians and nine centenarians). A total of 105 participants (70%) were female. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), and functional independence was evaluated using the Katz Index score. The maximal isometric grip strength was measured using a handgrip dynamometer. A moderation analysis was performed to test whether handgrip strength moderated the association between cognition and functional independence, stratified by biological sex and adjusted for body weight.
resultsHandgrip strength moderated the relationship between cognition and functional independence in both male and female older adults (p < 0.05). When handgrip strength was < 24.40 kg for males (42% of the study sample) and < 17.30 kg for female participants (60% of the study sample), the influence of cognitive function on functional independence was significant.
conclusionHandgrip strength moderates the relationship between cognition and functional independence in Brazilian nonagenarians and centenarians. This attenuating effect of muscle strength on the impact of cognitive function on functional independence was observed in both weaker male and female individuals. Longitudinal studies are needed to validate our findings, as the cross-sectional design limits the causal inferences.
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