ArticleObesity (Silver Spring, Md.)2025
Dietary macronutrient content and energy intake in the mouse: hedonic or homeostatic override?
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Macronutrient mixtures and interactions in health and disease.Nature reviews. Endocrinology · 2026Review
- Protein Decoys, Alcohol, and Energy Intake: Testing a Mechanistic-Ecological Model.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Dietary macronutrient content and energy intake in the mouse: hedonic or homeostatic override?Obesity (Silver Spring, Md.) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe objective of this study was to reconcile how two landmark mouse studies came to opposite conclusions regarding the relationship between dietary macronutrient composition and energy intake. Hu et al. concluded that dietary fat drives excess energy intake because its hedonic properties override energy homeostasis. Solon-Biet et al. concluded that energy intake increases with dietary fat owing to the dilution of protein and carbohydrates, with compensatory feeding for these nutrients dominating inhibitory feedback from fat.
methodsNutritional geometry was used to reanalyze data from Solon-Biet et al. and Hu et al.
resultsResults from the two studies are strongly concordant. Neither was designed to measure hedonics but, in both studies, the positive associations among dietary fat, food, and energy intakes are as predicted by compensatory feeding for dietary protein and carbohydrates without the need to impute hedonic effects of fat.
conclusionsWhereas conclusions cannot be drawn from either study regarding the role of hedonics, there is evidence for homeostatic feedback operating in both. We suggest that hedonic and homeostatic mechanisms likely interact, with homeostasis being more influential over the longer term. Therefore, "hedonic diversion" may be a more appropriate concept than "hedonic override" when considering energy consumption in mice and, perhaps, humans.
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Registered trials
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