Evidence map›Paper›PMID 40464201›Full record

ArticleJournal of biopharmaceutical statistics2025

BPED: A Bayesian basket design for pediatric trials with external data.

Yimei Li, Ying Yuan

Abstract read
In one paragraph

Article in Journal of biopharmaceutical statistics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yimei LiDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania & The Children's Hospital of Philadelphia, Philadelphia, USA.
Ying YuanDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA.

Funding

Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo · 2008 to 2026
$41.2M
The University of Texas MD Anderson Cancer Center SPORE in Ovarian CancerP50CA281701 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ROBERT C BAST, ANIL K SOOD · 2023 to 2026
$11.5M
Project 3: Inhibiting Oxidative Phosphorylation in Pancreatic CancerP50CA221707 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KOPETZ, SCOTT, MAITRA, ANIRBAN · 2019 to 2023
$11.0M
Coordinating and Data Management Center for Translational and Basic Science Research in Early LesionsU24CA274212 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Liang Li, Ying Yuan · 2022 to 2026
$3.5M
NCI NIH HHS P50 CA127001NCI NIH HHS P50 CA221707NCI NIH HHS P50 CA281701NCI NIH HHS U24 CA274212
6 · The paper itself

Abstract

The basket trial is a novel type of trial that evaluates one treatment in multiple indications (such as cancer types) simultaneously. One challenge of applying the basket trial design to pediatric studies is limited accrual, resulting in low statistical power. To address this issue, we propose a Bayesian

Indexed as

Basket trialsBayesian adaptive designborrow informationpediatricsubgroups

Identifiers

PMID40464201
PMCPMC12354168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.