Evidence map›Paper›PMID 40464199›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Prediction of 10-Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort.

Colin Vendrami, Elena Gonzalez Rodriguez, Guillaume Gatineau, Peter Vollenweider, Pedro Marques-Vidal, Olivier Lamy, Didier Hans, Enisa Shevroja

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In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Colin VendramiInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-0606-7279
Elena Gonzalez RodriguezInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-6512-6008
Guillaume GatineauInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-8440-391X
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-0765-896X
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-4548-8500
Olivier LamyInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-3684-2376
Didier HansInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-1826-5958
Enisa ShevrojaInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-6338-2948

Funding

Swiss National Science Foundation 320030_188886Swiss National Science Foundation SNSF 32473B_156978
6 · The paper itself

Abstract

backgroundMuscle strength, mass and function have been associated with falls, fractures and mortality, but the results vary between previous studies. We aimed to investigate the predictive ability of muscle strength and mass with 10-year incident fragility fractures.

methodsThis study included 1475 postmenopausal women aged 50-80 years (OsteoLaus cohort, Lausanne, Switzerland). Handgrip strength (HGS) was assessed. With a Jamar dynamometer and lean mass (LM) with dual x-ray absorptiometers (DXA) every 2.5 years for 10 years. LM, appendicular lean mass (ALM) and their indexes were assessed following the International Society for Clinical Densitometry (ISCD) guidelines. Main outcomes included hip, humerus and forearm low-trauma fractures from in-person interviews and vertebral fracture (VF) from lateral DXA screening. Secondary outcomes included falls and death. Baseline values were compared using two-sided t-test or Wilcoxon test (p < 0.0029 based on Bonferroni). Multivariate analysis included time to fracture with accelerated failure time (AFT) model and odds ratio (OR) with logistic regression, 95% confidence interval (CI) and C-Index or AUC.

resultsAfter 10.2 ± 0.4 years of follow-up, 944 women remained enrolled (age 73.0 ± 6.9 years, BMI 25.7 ± 4.8 kg/m

conclusionsLean mass and grip strength appear as independent risk factors for incident MOF, but with limited additional prediction performance. The prediction of fragility fractures differs between the fracture sites. Further studies with larger sample size, other muscle assessment modalities considering weight or fat mass as covariate, and broader ethnicities are needed.

Indexed as

Fractures, BoneOsteoporotic FracturesPostmenopauseAgedAged, 80 and overCohort StudiesFemaleHumansMiddle AgedMuscle Strengthdual‐x‐ray absorptiometryepidemiologyfragility fracturemuscleosteoporosispopulation studiessarcopenia

Identifiers

PMID40464199
PMCPMC12134769

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.