ReviewCurrent medicinal chemistry2026
Recent Advances in FLT3-Based Dual Inhibitors: A Promising Strategy for the Treatment of Acute Myeloid Leukemia.
Review in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Targeting FLT3 in Acute Myeloid Leukemia: Structural Insights and Key Challenges.ACS bio & med chem Au · 2026Review
- Review
- Dual-Targeting Strategy in Cancer Therapy: The Emerging Role of Pyrrolopyrimidine Scaffolds.Chemistry & biodiversity · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Acute Myeloid Leukemia (AML) is a hematological malignancy known for its aggressive nature, resistance to therapies, and high relapse rates. Approximately onethird of AML cases involve mutations in the FLT3 gene, making it a pivotal target for treatment strategies. Early FLT3 inhibitors demonstrated efficacy initially, yet subsequent issues with drug resistance and disease recurrence underscored the multifaceted challenges of AML management. Immunotherapy and combination therapies are effective strategies to overcome resistance, but there are limitations, such as toxic side effects. In contrast, FLT3 dual-target inhibitors exhibit excellent anti-tumor effects, while being safer and more controllable. Several of these inhibitors have progressed to clinical trials, underscoring their potential in advancing therapeutic options for AML. This review explores the synergistic potential of targeting FLT3 kinase in conjunction with other anti-cancer mechanisms and provides an overview of recent advancements in FLT3 dual-target inhibitors over the past decade.
Indexed as
Identifiers
40464185What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.