ArticleAngewandte Chemie (International ed. in English)2025
Non-Amphiphilic Antimicrobial Polymers.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Combating Antimicrobial Resistance with Hydrophilic and Eco-Friendly Membrane-Active Antibiotics Derived from Biological Nanoparticles.ACS nanoscience Au · 2026Article
- Reclaiming the Microbial Battlefield: Adjuvant Strategies to Overcome Antibiotic Resistance.Microorganisms · 2026Review
- Tertiary alkylamine-functionalized polyaspartamides with potent antibacterial activity.Bioactive materials · 2026Article
- Bactericidal Activities of Copolymers Incorporating Formylphenyl Motif for Targeting Surface Proteins.ACS polymers Au · 2025Article
- Non-Amphiphilic Antimicrobial Polymers.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Antimicrobial resistance (AMR) is a severe threat to modern healthcare and must be addressed to prevent millions of deaths in the coming decades. Antimicrobial polymers (APs) do not provoke resistance and are promising alternatives to conventional antibiotics. Classic APs possess an amphiphilic structure (cationic and hydrophobic). Herein, we question the necessity of amphiphilicity in APs and find that hydrophobicity is not an essential quality in these polymers. Combining cationic monomers with hydrophilic subunits containing hydrogen bond donors results in excellent antibacterial activity and concurrently low unspecific toxicity. Non-amphiphilic APs have the unique ability to cluster in isolated membrane regions, creating a supramolecular multivalence that enhances their membrane activity and aggregates bacterial cells. This effect, which only unfolds in the absence of hydrophobicity, opens new possibilities in the design of antimicrobial materials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.