ArticleJournal of dental research, dental clinics, dental prospects2025
Effect of bioactive glass toothpaste on the white spots around orthodontic brackets: A systematic review and meta-analysis.
Article in Journal of dental research, dental clinics, dental prospects, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Effectiveness of Bioactive Glass-Based Toothpaste for Early Childhood Caries Prevention: A Randomized Controlled Trial.International dental journal · 2026Trial
- Remineralising efficacy of bioactive glass and casein phosphopeptide amorphous calcium phosphate in white spot lesions or early enamel caries: A systematic review of randomised controlled trials.The Japanese dental science review · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: White spot lesions (WSLs), early indicators of tooth decay, are common in patients with fixed orthodontic appliances and can disrupt esthetic outcomes. Various methods have been proposed to prevent and treat WSLs, with bioactive glass products being one of the latest approaches. This study aims to evaluate the effect of bioactive glass toothpastes on WSLs around orthodontic brackets. Methods: Relevant articles were identified using databases such as PubMed, EMBASE, Cochrane's CENTRAL, Scopus, and Web of Science up to November 2023. The full texts of selected studies were retrieved, and their quality was assessed. The study included clinical and in vitro research. Four clinical studies (2015‒2023) were reviewed, with meta-analysis performed on three. A random-effects inverse variance meta-analysis was performed, and the quality of the evidence was graded using GRADE. Results: No significant difference was found between bioactive glass and fluoride toothpaste in remineralizing WSLs ( Conclusion: Bioactive glass toothpaste may be effective in remineralizing WSLs, though its efficacy is not significantly different from conventional fluoride toothpaste.
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Registered trials
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