Evidence map›Paper›PMID 40463998›Full record

ArticleFrontiers in physiology2025

Adaptation of thoracic and lumbar curvature and spinal muscle activity under changing gravity.

Anita Meinke, Alessandro Longhi Baez, Niklas Wiesmann, Oliver Ullrich, David A Green, Marcel Egli, Jaap Swanenburg

Abstract read
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anita MeinkeFaculty of Medicine, Institute of Aerospace Medicine, University of Zurich, Zurich, Switzerland.
Alessandro Longhi BaezFaculty of Medicine, Institute of Anatomy, University of Zurich, Zurich, Switzerland.
Niklas WiesmannFaculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland.
Oliver UllrichFaculty of Medicine, Institute of Aerospace Medicine, University of Zurich, Zurich, Switzerland.
David A GreenCentre of Human and Applied Physiological Sciences (CHAPS), King's College London, London, United Kingdom.
Marcel EgliFaculty of Medicine, Institute of Aerospace Medicine, University of Zurich, Zurich, Switzerland.
Jaap SwanenburgFaculty of Medicine, Institute of Aerospace Medicine, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The effect of micro-gravity on the lumbar and in particular thoracic regions is poorly understood. The aim of this study was to evaluate spinal curvature across the lumbar and thoracic region, and extensor muscle activity during acute micro-gravity and hyper-gravity induced by parabolic flight. In addition, the association between our proxy measure of spinal curvature, and extensor muscle activity in micro-gravity was investigated. Methods: During two ESA parabolic flight campaigns, 18 participants (8 female; 33 Results: Spinal flattening was observed during micro-gravity exposure, with changes most pronounced in the upper lumbar and lower thoracic spine. Mean-normalized area between the back and backpack decreased significantly in micro-gravity compared to earth-gravity (p = 0.001), but not during hyper-gravity (p = 1.00). The erector spinae responded heterogeneously to different gravity conditions across different assessment sites. Multifidus activity at L5 and erector spinae activity at L4 significantly decreased in micro-gravity compared to earth-gravity and hyper-gravity (p's Discussion/Conclusion: Parabolic flight-induced gravity changes caused upper lumbar and lower thoracic spine flattening in micro-g, while spinal curvature remained unchanged in hyper-g. In micro-g, Multifidus (L5) and Erector Spinae (L4) activity decreased, while in hyper-g, increased ES activity was observed at the upper middle transmitter. The maintained curvature and targeted muscle activation in hyper-g demonstrate protective mechanisms against increased axial loading, crucial for posture and injury prevention in both terrestrial and space environments. The spinal and muscular changes in micro-g indicate the need for targeted countermeasures during spaceflight, warranting comprehensive assessment in future research. Ethics: French "EST-III" (Nr-ID-RCB: 2022-A01696-37).

Indexed as

curvaturehyper-gravitylumbarmicro-gravityparabolic flightspine

Identifiers

PMID40463998
PMCPMC12131012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.