ArticleFrontiers in medicine2025
Second-harmonic generation microscopy of murine scleral remodeling by collagenase and reparative collagen mimetic peptides.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Myopia, resulting from an excessive axial elongation of the eye, is increasing worldwide at alarming rates. This investigation is a pilot study to determine if a novel collagen mimetic peptide (CMP) has a reparative function for scleral collagen organization after collagenase digestion, a cause for scleral thinning and increased creep rates, as this may have application in the pharmacologic treatment of myopia. Methods: Fresh, Results: SHG microscopy of the untreated scleral tissue showed a high degree of organization. Collagenase treatment resulted in a subjective straightening of the collagen fibers and a widening of the inter-fiber spacing with a statistically significant reduction of the OC ( Discussion: CMP treatment induced scleral collagen reorganization after collagenase digestion in murine models. These effects are consistent with inhibition or reversal of collagen enzymatic digestion. These results suggest that specific CMPs may have utility in the treatment of progressive myopia.
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