SynthesisFrontiers in oncology2025
Cumulative temporal association between assisted reproductive technology and childhood cancer: a systematic review and meta-analysis of observational studies.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pregnancy and perinatal complications in untreated subfertile couples following singleton spontaneous conception: a narrative review.Reproductive biology and endocrinology : RB&E · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Assisted reproductive technology (ART) has contributed to the birth of over 10 million children worldwide; however, its long-term health impacts, especially the potential risk of childhood cancer, continue to be a subject of debate. This study aims to examine the most current risk associations between ART and childhood cancer. Methods: We conducted a comprehensive search across PubMed, Embase, Web of Science, and Cochrane Library databases up to August 1, 2024. These studies aimed to explore the association between ART and childhood cancer risk, covering overall cancers, haematological malignancies, neural tumors, other solid tumors, and 11 specific cancers. Pooled analyses of risk estimates and 95% confidence intervals were conducted using random effects models, while cumulative meta-analyses were conducted to provide a time-based summary of the evidence. The study was prospectively registered on PROSPERO (CRD42024547262). Results: Sixteen large sample observational studies were included. Our findings showed a 21% increased risk of overall cancer in children conceived via ART (relative risk [RR] = 1.21, 95% CI, 1.11-1.33), with elevated risks also noted for haematological malignancies (RR = 1.16, 95% CI, 1.05-1.28), neural tumors (RR = 1.19, 95% CI, 1.07-1.32), and other solid tumors (RR = 1.48, 95% CI, 1.26-1.73). Six specific cancer types also demonstrated higher risks. The direction and magnitude of the effects remained relatively constant over time, while the degree of precision increased as data from newer studies were incorporated. Sensitivity analyses confirmed the robustness of these findings, and no publication bias was found. Conclusions: Our findings suggest a potential risk association between ART and childhood cancer, raising concerns regarding the future application of ART. These findings are critical in informing infertile couples considering ART about the potential risks involved. Clinical trial registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024547262.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.