ArticleJournal of inflammation research2025
AIM2-Driven Inflammation in Periodontitis: Mechanisms and Systemic Implications.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Genetic Liability to COPD and Periodontitis Risk: Integrative Genetic and Single-Cell Evidence Implicating Macrophage Reprogramming.International journal of chronic obstructive pulmonary disease · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Periodontitis is a chronic inflammatory condition that can be associated with systemic diseases like diabetes and cardiovascular disease. This study investigates the role of AIM2, a key inflammasome component, in periodontitis, focusing on its involvement in inflammation, DNA repair, and systemic disease links. Methods: AIM2 expression was analyzed in saliva and gingival crevicular fluid (GCF) from periodontitis patients. A mouse periodontitis model and in vitro gingival fibroblast experiments were used to study AIM2's role. Gene Set Enrichment Analysis (GSEA) and Protein-Protein Interaction (PPI) network analysis explored AIM2's systemic disease associations. Results: AIM2 was significantly upregulated in periodontitis patients and models, correlating with increased IL-1β, ASC, and Caspase-1. Immunofluorescence revealed AIM2's nuclear localization and co-localization with inflammatory markers. GSEA linked high AIM2 expression to cardiovascular diseases, while its suppression showed protective effects. PPI analysis identified interactions with DNA repair proteins (THOC2, SETX, ATM), suggesting a role in genomic stability and systemic disease. Conclusion: AIM2 drives local inflammation in periodontitis and may connect periodontitis to systemic diseases via DNA repair and systemic inflammation. This highlights AIM2 as a potential therapeutic target for managing periodontitis and associated systemic risks. Clinical Significance: Targeting AIM2 could offer a dual therapeutic strategy to control periodontal inflammation and mitigate systemic disease risks, such as cardiovascular disorders.
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