ArticleSleep advances : a journal of the Sleep Research Society2025
White matter microstructure statistically mediates associations between circadian rest/activity rhythms and cognition in older adults.
Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Longitudinal associations of rest-activity rhythms with executive function, plasma biomarkers, and clinical outcomes in older adults.Frontiers in aging neuroscience · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Aging is associated with disruptions in circadian rhythms, lower brain white matter integrity, and cognitive changes. However, whether white matter integrity serves as a potential mechanism linking circadian dysfunction to age-related cognitive abilities in older adults is unclear. We investigated cross-sectional associations of actigraphic circadian rest/activity rhythms (RARs) with whole-brain white matter tract fractional anisotropy (FA) and executive function performance in 156 older adults without dementia from the BIOCARD study (mean age = 71.3 years, including 19 with mild cognitive impairment and 137 cognitively unimpaired). We studied non-parametric metrics of RAR strength (relative amplitude [RA]), day-to-day stability (interdaily stability [IS]), and fragmentation (intradaily variability [IV]). After adjusting for age, sex, education,
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