Evidence map›Paper›PMID 40463803›Full record

ArticlePNAS nexus2025

Targeted disruption of the aralkylamine

Junko Kawabe, Natsumi Kawakami, Michiko Hirose, Yukari Kitamura, Mamoru Nagano, Yusuke Maruyama, Yohei Matsuyama, Teruki Hamano, Satoshi Koinuma, Takahiko Shiina and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Bezafibrate prolongs hypothermia induced by an AThe Journal of veterinary medical science · 2026
    Article
  3. A simplified protocol for vitrification of hamster embryos.The Journal of reproduction and development · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Junko KawabeThe Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8511, Japan.
Natsumi KawakamiThe Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8511, Japan.
Michiko HiroseRIKEN BioResource Research Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.
Yukari KitamuraThe Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8511, Japan.
Mamoru NaganoDepartment of Anatomy and Neurobiology, Kindai University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.ORCID https://orcid.org/0009-0000-3003-2909
Yusuke MaruyamaDepartment of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba 272-0827, Japan.
Yohei MatsuyamaThe Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8511, Japan.
Teruki HamanoThe Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8511, Japan.
Satoshi KoinumaDepartment of Anatomy and Neurobiology, Kindai University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.ORCID https://orcid.org/0000-0002-5397-4429
Takahiko ShiinaDepartment of Basic Veterinary Science, Laboratory of Physiology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan.
Momoko KobayashiThe Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8511, Japan.
Ritsuko MatsumuraThe Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8511, Japan.
Atsuhiko HattoriDepartment of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba 272-0827, Japan.
Yasufumi ShigeyoshiDepartment of Anatomy and Neurobiology, Kindai University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.ORCID https://orcid.org/0000-0002-3417-4469
Atsuo OguraRIKEN BioResource Research Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.
Koichi NodeDepartment of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, Saga, Saga 849-8501, Japan.
Makoto AkashiThe Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8511, Japan.ORCID https://orcid.org/0000-0002-1345-3338

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A definitive understanding of intrinsic functions of endogenous melatonin may require genetic manipulation or modification of its synthesizing enzymes. Here, we established Syrian hamsters, a seasonal mammal, carrying loss of function of aralkylamine

Indexed as

aralkylamine N-acetyltransferasecold adaptationhibernationmelatoninSyrian hamster

Identifiers

PMID40463803
PMCPMC12130684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.