ArticleFrontiers in endocrinology2025
Biological variation in serum thyroid, iron metabolism, and plasma bone metabolism biomarkers in patients with type 2 diabetes mellitus.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Variability in biomarkers is crucial for clinical decision-making in individuals with type 2 diabetes mellitus (T2DM). The biological variation (BV) of biomarkers associated with thyroid function, iron metabolism, and bone metabolism may show population-specific differences. This study aims to evaluate the biological variation of sixteen biomarkers in T2DM patients and compare these with variations observed in a healthy population. Methods: Twenty-four T2DM patients, aged 43 to 67 and in stable condition, were enrolled. Blood samples were collected biweekly for three months. Analysis of variance models were used to assess the BV, including within-subject BV (CV Results: Females exhibited lower CV Conclusions: BV data is critical for the precise interpretation of serial biomarker level changes in T2DM patients. It is deemed reasonable to use RCVs for four bone metabolism markers and five thyroid biomarkers, derived from a healthy population, as a reference for monitoring T2DM patients.
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