Evidence map›Paper›PMID 40463745›Full record

ArticleFrontiers in endocrinology2025

The impact of obesity and weight loss treatment on metabolic parameters, cardiovascular autonomic and sensory nerve function and

Anna Vágvölgyi, Viktor Vedelek, Nóra Keller, Dalma Szöllősi, Szilvia Lada, Attila Nemes, Péter Kempler, Adrienn Menyhárt, István Baczkó, Tamás Várkonyi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna Vágvölgyi *Endocrinology and Diabetology Center, Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Viktor Vedelek *Department of Genetics, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Nóra KellerInstitute of Clinical Pharmacy, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
Dalma SzöllősiInstitute of Reproductive Medicine, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
Szilvia LadaDirectorate of Nursing Management and Professional Education, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
Attila NemesEndocrinology and Diabetology Center, Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Péter KemplerDepartment of Medicine and Oncology, Semmelweis University, Budapest, Hungary.
Adrienn MenyhártDepartment of Medicine and Oncology, Semmelweis University, Budapest, Hungary.
István BaczkóDepartment of Pharmacology and Pharmacotherapy, Centre of Excellence for Interdisciplinary Research, Development and Innovation, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Tamás VárkonyiEndocrinology and Diabetology Center, Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Csaba Lengyel *Endocrinology and Diabetology Center, Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
János Zádori *Institute of Reproductive Medicine, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The global rise in obesity is linked to metabolic disorders, such as neuropathy and infertility. Our study aimed to analyze the effects of preconceptional weight loss in infertile women with obesity on peripheral sensory and cardiovascular autonomic nerve function, metabolic parameters, and the success of Methods: A retrospective cohort study included women with obesity and infertility undergoing weight optimization before IVF, alongside age-matched controls. Clinical and laboratory parameters, cardiovascular autonomic and peripheral sensory function, and body composition were evaluated before and following weight loss therapy. Results: Patients with obesity [n=58; mean ± SD; age: 33.1 ± 5.42 years; body mass index (BMI): 39.3 ± 6.90 kg/m Conclusion: Peripheral sensory neuronal impairments were detected in infertile women with obesity compared to the controls with normal BMI. Cardiovascular autonomic dysfunction was revealed by 30/15 and Valsalva-ratio in patients with obesity, suggesting the presence of parasympathetic dysfunction. Preconceptional weight loss improved metabolic parameters. Of the infertile female patients with obesity who reached their preconceptional target weight, 18.75% achieved spontaneous pregnancy without IVF, and 62.5% of those who underwent IVF successfully conceived.

Indexed as

Autonomic Nervous SystemFertilization in VitroInfertility, FemaleObesityWeight LossAdultBody Mass IndexFemaleHumansPilot ProjectsPregnancyRetrospective StudiesBMI – body mass indexcardiovascular autonomic nerve functionIVF – in vitro fertilizationmetabolic parametersobesityperipheral sensory nerve function

Identifiers

PMID40463745
PMCPMC12129780

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.