Evidence map›Paper›PMID 40463724›Full record

ArticleFrontiers in public health2025

The examination of physical function and cognitive outcomes in middle-to-older high-risk adults: an unsupervised clustering method.

Joshua L Gills, Megan D Jones, Anthony Campitelli, Sally Paulson, Cody Diehl, Charles Rodgers, Erica Madero, Jennifer R Myers, Kelsey Bryk, Omonigho Michael Bubu and 2 more

Abstract read
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joshua L GillsDepartment of Psychiatry, Aging Research in Sleep Equity & Dementia Prevention Program, Institute of Excellence in Health Equity, New York University Grossman School of Medicine, New York, NY, United States.
Megan D JonesExercise Science Research Center, University of Arkansas, Fayetteville, AR, United States.
Anthony CampitelliExercise Science Research Center, University of Arkansas, Fayetteville, AR, United States.
Sally PaulsonSt. Elizabeth Healthcare, Edgewood, KY, United States.
Cody DiehlExercise Science Research Center, University of Arkansas, Fayetteville, AR, United States.
Charles RodgersExercise Science Research Center, University of Arkansas, Fayetteville, AR, United States.
Erica MaderoNeurotrack Technologies, Inc., Redwoods City, CA, United States.
Jennifer R MyersNeurotrack Technologies, Inc., Redwoods City, CA, United States.
Kelsey BrykNeurotrack Technologies, Inc., Redwoods City, CA, United States.
Omonigho Michael BubuDepartment of Psychiatry, Aging Research in Sleep Equity & Dementia Prevention Program, Institute of Excellence in Health Equity, New York University Grossman School of Medicine, New York, NY, United States.
Jordan M GlennNeurotrack Technologies, Inc., Redwoods City, CA, United States.
Michelle GrayExercise Science Research Center, University of Arkansas, Fayetteville, AR, United States.

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Arline Faustin · 2020 to 2026
$28.4M
Using a Health Disparity Research Framework to examine mechanisms linking Obstructive Sleep Apnea with higher Alzheimer’s disease risk in older Blacks/African-AmericansR01AG082278 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OMONIGHO A MICHAEL Bubu · 2023 to 2026
$6.9M
Treatment of OSA on sleep-dependent memory and blood biomarkers in blacksRF1AG083975 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OMONIGHO A MICHAEL Bubu, Korey Kam · 2023 to 2026
$4.2M
Postdoctoral Research Training in Neurodegenerative Disorders and the Aging BrainT32AG052909 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Helen E Scharfman, THOMAS M WISNIEWSKI · 2017 to 2026
$2.5M
The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic WhitesK23AG068534 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUBU, OMONIGHO A MICHAEL · 2021 to 2025
$958k
NIA NIH HHS K23 AG068534NIA NIH HHS L30 AG064670NIA NIH HHS P30 AG066512NIA NIH HHS R01 AG082278NIA NIH HHS RF1 AG083975NIA NIH HHS T32 AG052909
6 · The paper itself

Abstract

Alzheimer's disease rates are expected to triple by 2050. Early detection and specific mitigation efforts are warranted to blunt the alarming increase. Physical function index (PFI) declines with age; additionally, higher PFI is associated with better cognitive functioning in middle-to-older age individuals. However, most studies utilize one domain of PFI to examine associations with cognition. Therefore, using clustering methods, the purpose of this investigation was to determine if high-risk individuals with higher PFI have better cognitive outcomes compared to individuals with lower PFI. Participants (

Indexed as

CognitionAgedCluster AnalysisFemaleHumansMaleMiddle Agedagingcardiovascularcognitionexercisemusclesphysical function

Identifiers

PMID40463724
PMCPMC12132019

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.