Multi-contrast laser endoscopy for in vivo gastrointestinal imaging.

Taylor L Bobrow, Mayank Golhar, Suchapa Arayakarnkul, Anthony A Song, Saowanee Ngamruengphong, Nicholas J Durr

Abstract readPreprint

In one paragraph

Article in ArXiv, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Updated by
Multi-contrast laser endoscopy for in vivo gastrointestinal imaging.2026

5 · Who and what money

Authors and funding

6 authors.

Taylor L BobrowDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.

Mayank GolharDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.

Suchapa ArayakarnkulDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, MD 21287.

Anthony A SongDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.

Saowanee NgamruengphongDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, MD 21287.

Nicholas J DurrDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.

Funding

Quantitative topographic endoscopy for improved screening of non-polypoid colorectal neoplasmsR21EB024700 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI DURR, NICHOLAS JAMES · 2018 to 2019

$623k

NIBIB NIH HHS R21 EB024700

6 · The paper itself

Abstract

White light endoscopy is the clinical gold standard for detecting diseases in the gastrointestinal tract. Most applications involve identifying visual abnormalities in tissue color, texture, and shape. Unfortunately, the contrast of these features is often subtle, causing many clinically relevant cases to go undetected. To overcome this challenge, we introduce Multi-contrast Laser Endoscopy (MLE): a platform for widefield clinical imaging with rapidly tunable spectral, coherent, and directional illumination. We demonstrate three capabilities of MLE: enhancing tissue chromophore contrast with multispectral diffuse reflectance, quantifying blood flow using laser speckle contrast imaging, and characterizing mucosal topography using photometric stereo. We validate MLE with benchtop models, then demonstrate MLE

Indexed as

colonoscopycolorectal cancerendoscopylaser speckle contrast imagingmultispectral imagingphotometric stereotissue oxygen saturationtopography

Identifiers

PMID40463704

PMCPMC12132275

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.