ArticleJournal of conservative dentistry and endodontics2025
Effect of continuous chelation irrigation on transforming growth factor-β1 release: An
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Etidronate-enhanced sodium hypochlorite irrigation in root canal therapy: A scoping review of efficacy and safety.Journal of clinical and experimental dentistry · 2026Article
- Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: Root canal irrigants and medicaments influence the growth factors released from dentin and create a conducive environment for regeneration. Aim: This study assesses the transforming growth factor-beta 1 (TGF-β1) release after using clodronate and etidronate as continuous chelating agents with two different medicaments calcium hydroxide (CH) and triple antibiotic paste (TAP). Settings and Design: This study involves an Materials and Methods: Ninety standard-sized dentin cylinders with apical sizes of 1 mm and 12 mm length were made from freshly extracted single-rooted premolars. Samples were randomly divided (45 each) and subjected to two intracanal medicaments, CH (Groups 1, 2, and 3) and TAP (Groups 4, 5, and 6). Three different irrigation protocols were followed: Group 1 and 4: Sequential use of 1.5% sodium hypochlorite (NaOCl) followed by 17% ethylenediaminetetraacetic acid (EDTA); Group 2 and 5: Etidronate + 1.5% NaOCl mixture; Group 3 and 6: 7.6% clodronate + 1.5% NaOCl mixture. The samples were stored in phosphate-buffered saline and subjected to enzyme-linked immunosorbent assay for TGF-β1quantification. Statistical Analysis Used: One-way analysis of variance and Tukey's Results: Growth factor release was significantly higher in the clodronate irrigation groups irrespective of the intracanal medicament used ( Conclusions: In the context of growth factor release, etidronate, and clodronate, which are regarded as substitutes for EDTA in regenerative endodontic procedures, performed equivalent to the gold standard irrigant, regardless of the medicament used.
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Registered trials
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