ArticleJournal of conservative dentistry and endodontics2025
Comparative evaluation of transforming growth factor-beta 1 release from dentin matrix with double antibiotic paste, probiotics, and simvastatin as intracanal medicaments: An
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- A preliminary antimicrobial investigation of lactobacillus bulgaricus probiotic supernatants as an intracanal medication against mature E. faecalis biofilm in an ex-vivo dentin blocks model.Clinical oral investigations · 2026Article
- Evaluation of antimicrobial efficacy of two commercially available probiotics againstJournal of conservative dentistry and endodontics · 2026Article
- Assessment of the dentine microhardness following the application of different intracanal medicaments. An in-vitro study.BDJ open · 2026Article
- Article
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Authors and funding
6 authors.
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Abstract
Aims: This study evaluates the release of transforming growth factor-beta 1 (TGF-β1) from root canal dentin on the application of double antibiotic paste (DAP), probiotics, and simvastatin as an intracanal medicament (ICM). Subjects and Methods: Forty-five extracted premolar teeth ( Statistical Analysis: For TGF-β1 release among groups, a one-way analysis of variance was conducted. Tukey's Results: TGF-β1 release was highest for simvastatin (294.27 pg/ml) followed by probiotics (201 pg/ml) and DAP (112.11 pg/ml). Conclusions: A statistically significant difference in TGF-β1 release was observed among the three test groups. Simvastatin and probiotics can effectively be used as an ICM in regenerative endodontics due to their potential to release high amounts of TGF-β1 from the dentin matrix.
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Registered trials
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