ArticleNeuro-oncology advances
Imaging the effects of treatment with TERT and EGFR inhibitors on glioblastoma: An MR study.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Telomerase reverse transcriptase (TERT) promoter mutations are observed in most glioblastoma (GBM) tumors, leading to TERT expression, which is crucial for tumor growth. Accordingly, inhibiting TERT or its upstream tumor-specific transcription factor GA-binding protein transcription factor subunit beta 1 (GABPB1) was shown to inhibit tumor growth. In addition, epidermal growth factor receptor (EGFR) was shown to signal upstream of TERT and GABPB1 and to control TERT expression, and EGFR inhibition also inhibits GBM growth. Methods: This study investigated the individual as well as combined effects of EGFR, TERT, and GABPB1 inhibition on cell and orthotopic rat models. We assessed cell proliferation, animal survival, tumor size, Results: When TERT or GABPB1 were inhibited simultaneously with EGFR, the combination treatment resulted in enhanced inhibition of cell and tumor growth as well as animal survival compared not only to controls but also to any of the single treatments. Our study also found that steady-state Conclusion: Our study points to the value of steady-state
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