SynthesisFrontiers in surgery2025
Incidence of new osteoporotic adjacent vertebral body fractures. A comparison between conservative treatment and vertebral body augmentation (vertebroplasty, kyphoplasty): a systematic review and meta-analysis.
Synthesis in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors of delayed union after surgical treatment in patients with osteoporotic vertebral compression fractures: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Sphereplasty with 3D porous titanium microspheres for thoracolumbar vertebral compression fractures: analysis of clinical efficacy and safety profile of a novel technique.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Analysis of risk factors and development of a predictive model for new vertebral fractures subsequent to percutaneous kyphoplasty in patients with single-segment osteoporotic vertebral compression fractures.BMC musculoskeletal disorders · 2026Article
- Multiphysics finite element analysis of vertebral stability in simulated osteolytic lumbar defects treated withFrontiers in bioengineering and biotechnology · 2026Article
- Effect of dominant cement distribution zone on pain relief after unipedicular percutaneous vertebroplasty.Frontiers in surgery · 2026Article
- Frailty and sarcopenia as independent predictors of early functional recovery in older adults with osteoporotic vertebral compression fractures: a retrospective cohort study.Frontiers in nutrition · 2026Article
- The Use of Polymethylmethacrylate Cement in Percutaneous Vertebroplasty Versus Conservative Management: How to Treat Osteoporotic Vertebral Compression Fractures.Medicina (Kaunas, Lithuania) · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Study design: A Systematic Review and Meta-Analysis. Purpose: To compare the incidence of New Adjacent Vertebral Fractures (ANVFs) in elderly patients with Osteoporotic Vertebral Compression Fractures (OVCFs) undergoing either percutaneous vertebral augmentation-via Vertebroplasty (PVP) or Kyphoplasty (PKP)-or Conservative Treatment (CT). Additionally, this study aims to identify potential risk factors associated with ANVFs. Hypothesis: The incidence of ANVFs does not significantly differ between patients managed with CT and those treated with PVP or PKP. Background: While the optimal treatment for OVCFs remains debated, PVP and PKP offer immediate stabilization, pain relief, and may help correct vertebral body wedging with minimal complications. However, a review of the literature reveals a limited number of meta-analyses comparing CT with PVP/PKP regarding the incidence of ANVFs. Materials and methods: Following PRISMA guidelines, a systematic search was conducted across PubMed, Cochrane, Web of Science, Scopus and Science Direct to identify studies published between 2005 and 2024 comparing surgical treatment with CT for ANVFs incidence. Nine studies (five RCTs and four retrospective comparative case-control studies) involving 1,930 patients were included in the analysis. Results: In RCTs, the analysis indicated a significant difference ( Conclusion: This meta-analysis, for the selected RCTs, shows that vertebral augmentation is associated with a lower incidence of ANVFs compared to CT. On the other hand, in the retrospective studies group there was no significant difference in the incidence of ANVFs between the two treatment groups (CT vs. PKP/PVP). Variations in study parameters, such as patient demographics and surgical techniques, may have affected these results. Further high-quality studies are needed to better understand the long-term effects of different treatment strategies on the incidence of ANVFs. Systematic Review Registration: PROSPERO (CRD420250509815).
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