The relationship between maternal glucose concentrations, gestational diabetes mellitus, placental weight, and placental vascular malperfusion lesions: a retrospective study of a U.S. pregnancy cohort.

Background: Gestational diabetes mellitus (GDM) is associated with increased placental weight and the presence of placental malperfusion lesions, likely related to high blood glucose. The relationship between high glucose without overt GDM, and placental characteristics is not well understood. Objective: To examine the relationships between glucose challenge test (GCT) concentrations, GDM, and placental characteristics associated with GDM. Methods: We conducted a secondary analysis of medical record data from singleton placentas sent to pathology at Northwestern Memorial Hospital (2011-2022; n=11,585). Data included maternal demographic variables, GCT concentrations, GDM diagnosis, placental weight, and vascular malperfusion lesions (accelerated villous maturation, increased syncytial knots, delayed villous maturation, and increased perivillous fibrin deposition). We classified GCT <140 mg/dL as pass and ≥140 mg/dL as fail. We categorized glucose groups into Results: Of placentas sent to pathology, 5% were from pregnancies with GDM and 17% from those who failed the GCT but did not get diagnosed with GDM. Compared to the Conclusion: GDM and high glucose concentrations without GDM were associated with heavier placentas; patients with GDM had a higher risk of delayed villous maturation.