Evidence map›Paper›PMID 40463559›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Polygenic and

Chelsie E Benca-Bachman, Samantha Cassidy, Rameez A Syed, Whitney L Barfield, Natalia Jaume-Feliciosi, Alicia K Smith, Seyma Katrinli, Abigail Powers, Yara Mekawi, Rohan H C Palmer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chelsie E Benca-BachmanBehavioral Genetics of Addiction laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.ORCID 0000-0002-5372-4593
Samantha CassidyBehavioral Genetics of Addiction laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Rameez A SyedBehavioral Genetics of Addiction laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Whitney L BarfieldBehavioral Genetics of Addiction laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Natalia Jaume-FeliciosiBehavioral Genetics of Addiction laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Alicia K SmithDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Seyma KatrinliDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Abigail PowersDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Yara MekawiDepartment of Psychological and Brain Sciences, University of Louisville, Louisville, KY, USA.
Rohan H C PalmerBehavioral Genetics of Addiction laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.ORCID 0000-0002-6809-9962

Funding

Genetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5M
Integrative Prioritization of Alcohol and Drug-Addiction Related Genetic LociR01DA042742 · NIDA · EMORY UNIVERSITY · PI PALMER, ROHAN HUGH CRAIG · 2018 to 2022
$1.7M
Advancing the Research Careers of Women and PEERs in Brain ScienceR25NS124530 · NINDS · BROWN UNIVERSITY · PI CARLOS D AIZENMAN, Diane Lipscombe · 2022 to 2026
$1.3M
Primary-Care Based Mindfulness Intervention for Chronically Traumatized IndividualsK23AT009713 · NCCIH · EMORY UNIVERSITY · PI LOTT, ABIGAIL POWERS · 2018 to 2021
$538k
Genetic and Trauma-Related Risk Factors for PTSD: From GWAS to FunctionR56MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2015 to 2015
$148k
NCCIH NIH HHS K23 AT009713NIDA NIH HHS R01 DA042742NIMH NIH HHS R01 MH071537NIMH NIH HHS R56 MH071537NINDS NIH HHS R25 NS124530
6 · The paper itself

Abstract

Aims: To estimate polygenic and polygene x environment contributions to alcohol consumption and problems in the context of childhood maltreatment and lifetime trauma. Design: Main and interaction effects models predicting alcohol consumption and problems were estimated using multiple linear regression. Covariates included age, sex, education, employment status, and ancestral principal components. Setting: USA. Participants: A sample of 2,114 Black adults (75% female; M Measurement: Polygenic scores (PGS) for trauma-related symptoms (re-experiencing: PGS Findings: Childhood maltreatment and lifetime trauma (excluding childhood abuse) were positively associated with alcohol consumption (AUDIT-C) (β Conclusions: Individuals with elevated genetic risk for AUD are more likely to consume alcohol and to develop worse alcohol problems in the context of lifetime trauma. Interventions focused on also minimizing the effects of trauma-exposure would be particularly beneficial among individuals at risk for AUD.

Indexed as

Alcohol Use DisorderAvoidanceGeneticHyperarousalRe-experiencingTrauma

Identifiers

PMID40463559
PMCPMC12132143

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.