In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
16 authors.
Rory BoylePenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0003-0787-6892 Nadia DehghaniPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-0385-7267 Sheina EmraniPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
Anil R WadhwaniPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-7007-2371 Melanie MatyiPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-4623-2080 Katheryn A Q CousinsPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0003-1879-2766 Emma RhodesPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-9053-0114 Brian NelsonPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
Shana D StitesDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0003-3994-4343 Sharon X XieDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA.ORCID 0000-0002-7886-4103 Laynie DratchPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-2179-3199 Vivianna M Van DeerlinDepartment of Pathology and Laboratory Medicine, University of Pennsylvania; 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-7400-9097 Allison SnyderPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-1857-928X David J IrwinPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-5599-5098 Corey T McMillanPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-7581-6405 Lauren MassimoPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.ORCID 0000-0002-3407-7335 Funding
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8MTechnology Identification and Training CoreP30AG073105 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DEMIRIS, GEORGE, KARLAWISH, JASON H · 2021 to 2025
$21.2MUnderstanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Sharon Xiangwen Xie · 2020 to 2026
$18.8MSTATISTICAL DATA ENCLAVE COREP30AG012836 · NIA · UNIVERSITY OF PENNSYLVANIA · PI COE, NORMA B · 1999 to 2024
$14.0MMultidimensional Approaches to Understanding Consequences and Mechanisms of Apathy in Frontotemporal DegenerationR01AG076832 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Lauren M Massimo · 2022 to 2026
$2.6MStudy of Cognitive Symptoms and Future Time Perspective in Preclinical Alzheimer's DiseaseK23AG065442 · NIA · UNIVERSITY OF PENNSYLVANIA · PI STITES, SHANA D. · 2020 to 2024
$886kNIA NIH HHS K23 AG065442NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG012836NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG073105NIA NIH HHS R01 AG076832
6 · The paper itselfAbstract
introductionNeighborhood deprivation is associated with shorter survival, cognitive impairment and neurodegeneration in aging and Alzheimer's disease. However, the association of neighborhood deprivation with disease progression in behavioral-variant frontotemporal degeneration (bvFTD) is unknown.
methodsWe examined associations between tertiles of neighborhood deprivation, using the Area Deprivation Index (ADI), and survival in 311 individuals clinically diagnosed with bvFTD from the Penn FTD Center. In a subset (n=161) with complete baseline data across measures of global cognition, executive function, and language, we examined the association of ADI with longitudinal change.
resultsCompared to adults living in the least deprived neighborhoods, those living in the most deprived neighborhoods showed shorter survival after symptom onset and faster decline in global cognition, executive and language functions, independent of genetic risk. DISCUSSION: Living in more deprived neighborhoods was associated with an accelerated disease course in bvFTD, highlighting an important socioeconomic disparity in disease prognosis.
Indexed as
Area Deprivation IndexBehavioral-Variant Frontotemporal DegenerationBrain Health EquityCognitive DeclineExecutive FunctionFrontotemporal DegenerationNeighborhood deprivationReserveResilienceSocial and structural determinants of healthSocioeconomic Status
Identifiers
PMID40463548
PMCPMC12132133
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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