Evidence map›Paper›PMID 40463539›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Cholera rapid diagnostic tests at the host-microbe interface: Key Considerations for Global Deployments.

S M Ahmed, Md Abu Sayeed, I Sriguha, E T Cato, A Creasy-Marrazzo, K Islam, Md I Ul Khabir, Md T R Bhuiyan, Y Begum, Md Taufiqul Islam and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

S M AhmedDepartment of Epidemiology, Emory University, Atlanta, GA, USA.
Md Abu SayeedDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
I SriguhaDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
E T CatoDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
A Creasy-MarrazzoDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
K IslamInfectious Diseases Division International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Md I Ul KhabirInfectious Diseases Division International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Md T R BhuiyanInfectious Diseases Division International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Y BegumInfectious Diseases Division International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Md Taufiqul IslamInfectious Diseases Division International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Zahid Hasan KhanInfectious Diseases Division International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
E FreemanDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
A VustepalliDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
L BrinkleyDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
M KamatDepartment of Chemistry, University of Florida, Gainesville, FL, USA.
L S BaileyDepartment of Chemistry, University of Florida, Gainesville, FL, USA.
N MadiDepartment of Microbiology & Immunology, McGill University, Montréal, Canada.
F QadriInfectious Diseases Division International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
B J ShapiroDepartment of Microbiology & Immunology, McGill University, Montréal, Canada.ORCID 0000-0001-6819-8699
D T LeungDepartment of Internal Medicine, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0001-8401-0801
K B BassoDepartment of Chemistry, University of Florida, Gainesville, FL, USA.
D A SackDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
J R AndrewsDivision of Infectious Diseases and Geographic Medicine, School of Medicine, Stanford University, Stanford, California.
A I KhanInfectious Diseases Division International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
E J NelsonDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.

Funding

Epidemiology and Ecology of Cholera in AfricaR01AI123422 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Amanda Kay Debes, DAVID A SACK · 2017 to 2026
$6.6M
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
The evaluation of a mHealth platform for diarrheal disease decision support and real-time epidemiologyR21TW010182 · FIC · UNIVERSITY OF FLORIDA · PI KHAN, ASHRAFUL ISLAM, NELSON, ERIC JORGE · 2016 to 2017
$320k
FIC NIH HHS R21 TW010182NIAID NIH HHS R01 AI123422NIH HHS S10 OD021758Wellcome Trust
6 · The paper itself

Abstract

Background: Effective cholera outbreak response requires accurate bedside rapid diagnostic tests (RDTs) because access to laboratories is often limited. Formative studies suggest cholera diagnostics have multiple vulnerabilities, including antibiotics and predation by bacteriophage ('phage') specific to Methods: We conducted a prospective nationwide study in Bangladesh among over 2000 patients with diarrhoeal disease to characterize how these vulnerabilities impact RDT performance. Assays included culture, qPCR and mass spectrometry. Findings: With the current gold standard of culture or qPCR Interpretation: Cholera RDTs have critical limitations that require consideration in global deployments. Inclusion of phage detection in diagnostic criteria may improve case detection which requires further study. The impact of these findings likely extends to other diseases where diagnostics share similar vulnerabilities.

Indexed as

AMRantibioticsantimicrobial resistancebacteriophageBangladeshCholeradiarrheadiarrhoeaoutbreakphagerapid diagnostic testRDTVibrio cholerae

Identifiers

PMID40463539
PMCPMC12132138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.