ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Predictive Value of Bone Metabolism Marker PINP in the Risk of Diabetic Retinopathy: A Cross-Sectional Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Construction of a dynamic prediction model for diabetic retinopathy risk in adults with adult-onset type 1 diabetes: a real-world longitudinal cohort study.Frontiers in clinical diabetes and healthcare · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Given the association between diabetic microvascular disease and bone metabolism, we aimed to investigate the correlation between the concentration of the serum bone turnover marker procollagen type I N-terminal propeptide (PINP) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in this study. Methods: This was a cross-sectional study. T2DM patients aged ≥18 years were consecutively recruited from the inpatient population of the Department of Endocrinology at Nanjing Drum Tower Hospital, between January 2016 and January 2018, and participants were divided into DR and non-DR groups. We compared clinical and laboratory data of patients in the two groups. Logistic regression analysis was employed to investigate the overall risk of DR at the PINP quartiles. Receiver operating characteristic (ROC) curves were conducted to estimate the predictive power of PINP for DR. Results: A total of 509 patients with T2DM were included in this study (390 males and 194 females), including 148 patients with DR. Age and diabetes duration were independent risk factors for DR, PINP was also an independent protective factor (all P < 0.05). According to the interquartile range of PINP, all participants were divided into four groups. After adjustment for confounders, patients in Q2, Q3 and Q4 all had a decreased risk of DR compared with Q1 group (OR 0.501, 95% CI 0.280~0.894; OR 0.289, 95% CI 0.157~0.533; OR 0.077, 95% CI 0.036~0.165) respectively. Meanwhile, the AUC of DR diagnosed by the combined diagnostic model of PINP with age and duration of diabetes was 0.8271 (95% CI: 0.7911-0.863). Conclusion: The PINP level is associated with diabetic retinopathy in patients with T2DM, and PINP was an independent protective factor for DR and may help to predict its progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.