Evidence map›Paper›PMID 40463439›Full record

ArticleFrontiers in microbiology2025

Azithromycin treatment response as a probe to attribute bacterial etiologies of diarrhea using molecular diagnostics: a reanalysis of the Antibiotics for Children with Severe Diarrhea (ABCD) trial.

Jennifer Cornick, Sarah Elwood, James Platts-Mills, Patricia Pavlinac, Karim Premji Manji, Christopher R Sudfeld, Christopher P Duggan, Queen Dube, Naor Bar-Zeev, Karen Kotloff and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Evaluation of the performance and feasibility of RLDT in detectingmedRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jennifer CornickMalawi Liverpool Wellcome Trust Research Programme, Queen Elizabeth Central Hospital, Blantyre, Malawi.
Sarah ElwoodDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United States.
James Platts-MillsDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United States.
Patricia PavlinacDepartment of Global Health, University of Washington, Seattle, WA, United States.
Karim Premji ManjiDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Christopher R SudfeldDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Christopher P DugganDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, United States.
Queen DubeMalawi Liverpool Wellcome Trust Research Programme, Queen Elizabeth Central Hospital, Blantyre, Malawi.
Naor Bar-ZeevInternational Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Karen KotloffCenter for Vaccine Development and Global Health, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States.
Samba O SowCentre pour le Développement des Vaccins, Bamako, Mali.
Sunil SazawalCenter for Public Health Kinetics, New Delhi, India.
Benson SingaChildhood Acute Illness and Nutrition Network, Nairobi, Kenya.
Judd L WalsonChildhood Acute Illness and Nutrition Network, Nairobi, Kenya.
Farah Naz QamarDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Tahmeed AhmedNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Ayesha De CostaDepartment of Maternal, Child, and Adolescent Health and Aging, World Health Organization, Geneva, Switzerland.
Elizabeth T Rogawski McQuadeDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States.

Funding

World Health Organization 001
6 · The paper itself

Abstract

Background: Multi-pathogen molecular diagnostics enhance our understanding of the pathogen-specific burden of diarrhea. However, attributing etiology remains challenging in high-burden settings where coinfections are common. The Antibiotics for Children with severe Diarrhea (ABCD) trial provides a unique opportunity to leverage azithromycin treatment response to identify bacterial diarrhea. Methods: We analyzed data from 6,692 children with watery diarrhea enrolled in ABCD (2017 to 2019) who were randomized to receive azithromycin or placebo. We modelled the heterogeneity in the azithromycin treatment response by the enteric pathogen quantity detected by quantitative PCR using log-binomial regression. Results: Azithromycin treatment response varied by pathogen quantity, with the strongest effect observed for Conclusion: The observed associations between azithromycin treatment response and pathogen quantity for

Indexed as

azihtromycinchildrendiarrheaetiologyRT-PCRShigella

Identifiers

PMID40463439
PMCPMC12130904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.